National Repository of Dissertations in Serbia
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   NaRDuS home
  • Универзитет у Београду
  • Медицински факултет
  • View Item
  •   NaRDuS home
  • Универзитет у Београду
  • Медицински факултет
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Postizanje hemodinamske stabilnosti infuzionim rastvorima ciljanom nadoknadom tečnosti u kolorektalnoj hirurgiji

Hemodynamic stability achievement with infusion solutions by application of goal directed fluid therapy in colorectal surgery

Thumbnail
2018
Disertacija.pdf (4.000Mb)
IzvestajKomisije18492.pdf (94.25Kb)
Author
Cvetković, Ana D.
Mentor
Kalezić, Nevena
Committee members
Miličić, Biljana
Ivanović, Branislava
Simić, Dušica
Vulović, Tatjana
Metadata
Show full item record
Abstract
Ciljevi istraživanja su procena uticaj primene kristaloidnih rastvora ili kombinacije koloidnih i kristaloidnih rastvora i njihovih volumena na vrednosti udarnog i minutnog volumena srca tokom kolorektalne operacija kao i utvrđivanje razlika u: količini neophodne tečnosti, vremenu do uspostavljanja intraoperativne hemodinamske stabilnosti, bilansu tečnosti, učestolasti primene vazopresora i inotropa, pojavi komplikacija, ukupnoj dužini hospitalizacije u ispitivanoj grupi. Metodologija: Ova randomizovana prospektivna studija obuhvata 80 pacijenata koji su se podvrgli elektivnoj hirurgiji zbog kolorektalnog karcinoma, na Klinici za onkološku hirurgiju Instituta za onkologiju i radiologiju Srbije. U kontrolnoj grupi koja je primala kristaloidni rastvor i u ispitivanoj grupi, koja je primala kombinaciju koloida i kristaloida, nadoknada je vršena hemodinamskim algoritmom. Merene su hemodinamske varijable i praćene su komplikacije i dužina boravka u bolnici. Rezultati: Pacijenti obe grupe bi...li su homogeni po osnovnim osobinama i pretećim oboljenjima. U kristaloidno-koloidnoj grupi postignute su više vrednosti udarnog volumena srca nakon sat vremena, do kraja operacije i nakon 24 sata. Vrednost minutnog volumena srca bila je značajno veća u ovoj grupi na kraju anestezije. Komlikacije su bile učestalije u kristaloidnoj grupi. Zaključak: Kombinacija rastvora daje veće vrednosti udarnog i minutnog volumena srca, brži oporavak i kraći ostanak u bolnici.

Study aim is to estimate impact of crystalloids or colloids and crystalloids and their volumes on stroke volume and cardiac output during colorectal surgery and to estimate difference in volumes of these solutions, time till achieved hemodynamic stability, fluid balance, incidence of vasoactive drugs use, appearance of complications, duration of hospital stay. Methods: This is a randomized prospective study with 80 patients who underwent elective colorectal surgery on Clinic for oncological surgery of Institute for oncology and radiology of Serbia. In a control group, patients who received crystalloids and in the research group, patients who received colloids and crystalloids, we used hemodynamic algorithm for goaldirected fluid therapy. We measured hemodynamic variables such as stroke volume, cardiac output, cardiac index, mean arterial pressure, oxygen delivery. We recorded complications and duration of hospitalization. Results: Patients in both groups were homogenous according to ba...seline characteristics and comorbidity. Crystalloid-colloid group achieved higher values of stroke volume one hour from anesthesia induction till the end of surgeru, and after 24 hours. Also values of stroke volume and cardiac output were higher after 24 hours. Incidence of complications were higher in crystalloid group according to Clavien-Dindo clasiffication and also these patients had a longer period of hopitalisation. Both groups had a good hemodynamics. Conclusion: Combination of solutions provide higher values of stroke volume and cardiac output, faster postoperative recovery and faster hospital discharge.

Faculty:
University of Belgrade, School of Medicine
Date:
25-09-2018
Keywords:
Kristaloidi / Crystalloids / colloids / goal-directed therapy / colorectal surgery / stroke volume / cardiac output / koloidi / ciljana nadoknada tečnosti / kolorektalna hirurgija / udarni volumen srca / minutni volumen srca
[ Google Scholar ]
URI
http://nardus.mpn.gov.rs/handle/123456789/10278
http://eteze.bg.ac.rs/application/showtheses?thesesId=6310
https://fedorabg.bg.ac.rs/fedora/get/o:18970/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50776847

DSpace software copyright © 2002-2015  DuraSpace
About NaRDus | Contact us

OpenAIRERCUBRODOSTEMPUS
 

 

Browse

All of DSpaceUniversities & FacultiesAuthorsMentorCommittee membersSubjectsThis CollectionAuthorsMentorCommittee membersSubjects

DSpace software copyright © 2002-2015  DuraSpace
About NaRDus | Contact us

OpenAIRERCUBRODOSTEMPUS