Kvalitet života kod bolesnika sa sarkoidozom koji imaju promene na očima
The quality of life of sarcoidosis patients with ocular changes
Author
Popević, Ljubica S.Mentor
Vučinić Mihailović, VioletaCommittee members
Marković-Denić, LjiljanaJovanović, Dragana M.
Škodrić-Trifunović, Vesna

Resan, Mirko
Metadata
Show full item recordAbstract
Sarkoidoza je multisistemska bolest nepoznate etiologije koja se karakteriše
prisustvom nekazeifikujućih granuloma u tkivima i organima. Složena patogentska
osnova sarkoidoze i često nepredvidiv tok bolesti, uzrokuje značajan poremećaj
kvaliteta života obolelih. Posebnu grupu u tom smislu predstavljaju oboleli od
sarkoidoze sa promenama na očima, koje uzrokuju značajan pad opšteg i organ
specifičnog (vezanog za vid) kvaliteta života.
Materijal i metode: Opservacijsko (deskriptivno) kliničko istraživanje (studija preseka)
obavljeno je u Klinici za pulmologiju Kliničkog centra Srbije i Domu zdravlja
Voždovac. Prospektivnom analizom je obuhvaćen uzorak od 80 bolesnika sa
dokazanom sarkoidozom. Svim bolesnicima je uzeta detaljna anamneza sa procenom
kliničkih simptoma, kao i kompletan oftalmološki pregled. U odabranoj grupi od 20
bolesnika učinjena je paracenteza i analiza aktivnosti angiotenzin konvertujućeg enzima
(ACE) u očnoj vodici. Svi bolesnici su podeljeni u dve grupe (sa i bez očn...ih promena) i
popunjavali su upitnike za procenu kvaliteta života. Dobijeni rezultati su kodirani, uneti
u bazu podataka i analizirana je statistička veza podataka dobijenih ispitivanjem.
Ciljevi ispitivanja su bili: utvrditi razliku u kvalitetu života bolesnika sa sistemskom
sarkoidozom kod kojih postoje i promene na očima u odnosu na one bolesnike bez
očnih promena, ispitati korelaciju demografskih i kliničkih faktora na kvalitet života
bolesnika sa sistemskom sarkoidozom i sa očnim promenama, ispitati uticaj aktivnosti
ACE u očnoj vodici na očne manifestacije sarkoidoze.
Rezultati: Bilo je više muškaraca (56,25%) nego žena (43,75%) u obe grupe zajedno.
Odnos polova iznosio je 1,28 u korist muškaraca. Žene oboljevaju od očne sarkoidoze
češće od muškaraca i ta razlika je statistički značajna. U odnosu na sva pitanja iz
upitnika NEI 25 (National Eye Institute- Nacionalni institut za oči) statistički je visoko
značajna razlika između odgovora bolesnika sa i bez očnih promena u smislu lošijeg
kvaliteta života kod onih sa očnim promenama. U odnosu na sva pitanja iz upitnika
KSQ (King’s Sarcoidosis Questionairre- Upitnik Kraljevskog koledža za sarkoidozu)
uočena je visoko statistički značajna razlika u kvalitetu života vezanom za vid ali i u
opštem kvalitetu života po svim pitanjima između dve grupe ispitanika s tim što su
pacijenti s očnim promenama imali značajno niže skorove. Bolesnici sa očnom
sarkoidozom su imali povišene vrednosti ACE u očnoj vodici...
Sarcoidosis is a multisystemic disease of unknown aetiology
characterized by the presence of non-caseating granulomas in tissues and organs. The
complex pathogenic basis of sarcoidosis and the often unpredictable course of the
disease causes a significant disorder of the quality of life of thepatients. A particular
group are patients with sarcoidosis with changes in the eyes, which cause a significant
decrease in the general and organ specific (related to vision) quality of life.
Material and Methods: Observational (descriptive) clinical research (cross-section
study) was carried out at the Clinic for pulmonology of the Clinical Center of Serbia
and the Health Center Vozdovac. A prospective analysis included a sample of 80
patients with proven sarcoidosis. In all patients a detailed history was taken, with
assessment of clinical symptoms, as well as a complete ophthalmological examination.
In a specially selectedgroup of 20 patients, paracentesis and analysis of ACE activity in
aqueous... humor was performed. All patients were divided into two groups (with and
without eye changes) and filled out questionnaires for the assessment of quality of life.
The obtained results are encoded, entered into the database, and the statistical analysis
performed.
The objectives of the study were: to determine the difference in the quality of life of
patients with systemic sarcoidosis in whom there are changes in eyes compared to those
patients without eye changes, to examine the correlation of demographic and clinical
factors to the quality of life of patients with systemic sarcoidosis and eye changes,
examine the effect angiotensin-converting enzyme activity (ACE) in the aqueous humor
on eye manifestations of sarcoidosis.
Results: There were more men (56.25%) than women (43.75%) in both groups
together. The gender ratio was 1.28 for men. Women suffer from ocular sarcoidosis
more often than men, and this difference is statistically significant. Regarding all the
questions from the NEI 25 questionnaire, a statistically significant difference was
observed between the patients with and without ocular changes in terms of poor quality
of life in those with eye changes. Regarding all the questions from the King's
Sarcoidosis Questionairre questionnaire (KSQ), a highly statistically significant
difference in the quality of life related to vision and overall quality of life was observed
on all issues between the two groups of patients and patients with ocular sarcoidosis had
significantly lower scores. Patients with eye sarcoidosis had elevated ACE levels in the
aquous humor...