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Prognostic value of ultrasonogrphic findings of hands and feet joints in structural damage progression in patients with early reumathoid arthritis

dc.contributor.advisorDamjanov, Nemanja
dc.contributor.otherStupar-Vujasinović, Nada
dc.contributor.otherŠefik-Bukilica, Mirjana
dc.contributor.otherKonstantinović, Vitomir
dc.creatorProdanović, Slavica Ž.
dc.date.accessioned2018-11-09T16:41:48Z
dc.date.available2018-11-09T16:41:48Z
dc.date.available2020-07-03T08:50:14Z
dc.date.issued2018-09-26
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/10125
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=6133
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:18599/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50661135
dc.description.abstractDosada[nja istraživanja ukazuju na pouzdanost primene muskuloskeletnog ultrazvuka (MSUZ) u oceni nalaza inflamacije kao i strukturnog oštećenja na perifernim zglobovima. Cilj ovog rada je bio da se proceni strukturno oštećenje na zglobovima šaka i stopala kod bolesnika sa dijagnozom ranog reumatoidnog artritisa (RA) i trajanjem simptoma bolesti ≤12 meseci, primenom MSUZ i utvrditi prognostički značaj bazalnog ultrazvučnog (UZ) nalaza nakon 6 meseci lečenja bolesnika. Metod. U studiju praćenja uključeno je 65 bolesnika, sa dijagnozom ranog RA (EULAR/ACR kriterijumi iz 2010 godine), trajanja ≤12 meseci postavljenom u ambulantnim/bolničkim uslovima Instituta za reumatologiju u Beogradu, u periodu 2012-2014. god. Uključujući kriterijumi za istraživanje bili su: 1. odsustvo predhodne primene glikokortikoidne/DMARD terapije 2. odsustvo nalaza strukturnih promena na urađenoj radiografiji šaka i stopala 3. odsustvo drugih inflamacijskih ili degenerativnog oboljenja zglobova težeg stepena. Kontrolnu grupu je činilo 30 zdravih. Na početku/ nakon 6 meseci praćenja, urađeni su: pregled sistema za kretanje; UZ pregled zglobova šaka i stopala, prema preporukama OMERACT grupe experata. Pregled je obavljen lineranom sondom, 8-16 MHz, aparata Esaote My Lab- 70. Nalaz inflamacije na zglobovima ocenjivan je semikvantitativno (Sckudlarek-ov metod) a U Z n alaz erozije kvalitativno uz ocenu veličine i zapremine iste; laboratorijski nalazi: brzina sedimentacije eritrocita (SE), C reaktivni protein (CRP), nalaz i koncentracija reumatoidnog faktora (RF), antitela na ciklični citrulisani peptid (ACPA) i matrixmetaloproteinaze 3 (MMP-3); radiografsko snimanje šaka i stopala; ispitivanje funkcijskog statusa (HAQ upitnik); posle 6 meseci MR šaka. Podaci su obrađeni u SPSS 16 sistemu...sr
dc.description.abstractMusculoskeletal ultrasound (MSU) is been proven clinical method in reliable both joints inflammation and structural damage assessing. The aims of this study were to evaluate structural damage progression of the hands and feet joints assessed by ultrasonography (US), in patients (pts) with early, treatment naïve rheumatoid arthritis (RA), without X-ray visible erosions, and to estimate the prognostic value of basal ultrasound (UZ) findings after 6 months of treatment. Method. Sixty-five pts with symptoms duration of ≤12 months and diagnosis of early RA, according to the 2010 (ACR/EULAR) classification criteria, in Institute of rheumatology in Belgrade, were included in a prospective clinical study during the 2012-2014 yrs.. The following including criteria had to be fulfilled 1. absence of prior use of glycocorticoid / DMARD therapy; 2. absence of finding of structural damage on X-ray of the hands and foot 3. absence of the others inflammatory or severe degenerative joint‘s disorders. The 30 healthy control, were recruited among the staff of the Institute. At the study entry and after 6 months of treatment, all pts. were underwent on: clinical examination; laboratory testing (ESE, CRP, RF, ACPA, MMP- 3); radiographic and US examination which was performing by 16 MHz linear probe of Esaote My Lab 70 high resolution machine. OMERACT US group definition was used to detect the presence of synovial fluid and hypertrophy, PD signal, as well as bony erosion presence, at the level of hands and feet joints. US findings was assessed by Sckudlarek semiquantitaive method. The size and volume of erosions were rated. After 6 months MR of hand was performed. The data were processing in SPSS package. Results: Complete results were obtained from 63 included pts...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Београдуsr
dc.subjectultrazvuksr
dc.subjectultrasounden
dc.subjectzglobovi šakasr
dc.subjectzglobovi stopalasr
dc.subjecterozijasr
dc.subjectrani reumatoidni arthritissr
dc.subjectprognozasr
dc.subjectstrukturno oštećenjesr
dc.subjectPower Doppler signalsr
dc.subjectantitela na cikličnisr
dc.subjectcitrulisani peptidsr
dc.subjectmatriks metalproteinaza-3sr
dc.subjecthands jointsen
dc.subjectfeeten
dc.subjectearly RAen
dc.subjectprognostic valueen
dc.subjectstructural damageen
dc.subjectPower Doppler signalen
dc.subjectAnti-citrullinated ptotein antibodyen
dc.subjectmatrix metallproteinases-3en
dc.titlePrognostički značaj ultrazvučnog nalaza u proceni strukturnog oštećenja zglobova šaka i stopala kod bolesnika sa početnim reumatoidnim artritisomsr
dc.title.alternativePrognostic value of ultrasonogrphic findings of hands and feet joints in structural damage progression in patients with early reumathoid arthritisen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractДамјанов, Немања; Шефик-Букилица, Мирјана; Ступар-Вујасиновић, Нада; Константиновић, Витомир; Продановић, Славица Ж.; Прогностички значај ултразвучног налаза у процени структурног оштећења зглобова шака и стопала код болесника са почетним реуматоидним артритисом; Прогностички значај ултразвучног налаза у процени структурног оштећења зглобова шака и стопала код болесника са почетним реуматоидним артритисом;
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/9799/Disertacija.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/9800/IzvestajKomisije18299.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/9800/IzvestajKomisije18299.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/9799/Disertacija.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_10125


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