Komparativna analiza parametara višeredne kompjuterizovane tomografije i patohistoloških nalaza kod karcinoma pluća
Comparative analysis of parameters for multislice computed tomography and histopathological findings in lung cancer
Докторанд
Antuleska-Belčeska, Gordana V.Ментор
Petrović, SlađanaЧланови комисије
Radovanović, ZoranStojanov, Dragan
Ristić, Lidija
Stošić-Opinćal, Tatjana
Метаподаци
Приказ свих података о дисертацијиСажетак
COMPARATIVE ANALYSIS OF PARAMETERS FOR MULTI-SLICE COMPUTED
TOMOGRAPHY AND HISTOPATHOLOGICAL FINDINGS IN LUNG CANCER
AIM: The main aim of this research is to demonstrate that the MSCT is a modality of choice,
the ''gold standard'' for diagnosis and staging of lung cancer. Comparison of CT findings with
histopathologically confirmed TNM stage confirmed also ability of this imaging modality in
determination of morphological characteristics of certain histologic types of lung cancer.
PATIENTS AND METHODS: This research represents a prospective - retrospective study
of patients with lung cancer. A total of 173 patients with histologically confirmed NSCLC
and SCLC were included. In the interest of the study, and to facilitate statistical analysis, all
patients were divided into two groups: operable (117) and inoperable (56). We analyzed the
CT morphological characteristics of lung cancer as well as demographic characteristics.
RESULTS: Mean age of the participants was 60.2 ± 8.7 years. Wit...h regard to smoking
status, the majority were smokers, the period of smoking was over 20 years, but in relation to
duration and intensity of smoking patient were divided into three groups: smokers who
smoked more than 20 years and more than a pack per day - 49.13%, smokers who smoked
more then 20 years and a pack per day – 5.78% and group of smokers who smoked more than
20 years but intermittently - 15.61%. Occupational exposure is positive in 16.18% of
patients, while a positive family history is present in 20.81% of patients. The most common
type of cancer is adenocarcinoma 40.46%, followed by squamous cell carcinoma 34.68%.
The sensitivity of MSCT imaging modality in T staging of lung cancer, taking
pathohistological results as reference value, ranges from 72.73% to 99.8% and specificity
ranges from 94% to 99.3%, while the global accuracy ranges from 97.43% to 98.29%. The
sensitivity of MSCT in N staging of lung cancer ranges from 68.7% to 71%, the specificity
was higher ranging from 92.3 to 94.1%, while the global accuracy ranges from 85.3% to
86.1%.
CONCLUSION: In our study, we confirmed that MSCT is the ''gold standard'' in the
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preoperative staging of patients with lung cancer. Multi detector computerized tomography
provides detailed information not only on tumor size but also provides information on
morphological characteristics of tumor.