Приказ основних података о дисертацији
Sinteza i karakterizacija rutenijum-arenskih kompleksa sa N, S ili O donorskim ligandima
Synthesis and characterization of ruthenium-arene complexes with N, S or O donor ligands
dc.contributor.advisor | Grgurić-Šipka, Sanja | |
dc.contributor.other | Sabo, Tibor | |
dc.contributor.other | Opsenica, Dejan | |
dc.contributor.other | Aranđelović, Sandra S. | |
dc.creator | Nikolić, Stefan R. | |
dc.date.accessioned | 2024-03-13T15:48:40Z | |
dc.date.available | 2024-03-13T15:48:40Z | |
dc.date.issued | 2019-06-06 | |
dc.identifier.uri | https://eteze.bg.ac.rs/application/showtheses?thesesId=9584 | |
dc.identifier.uri | https://uvidok.rcub.bg.ac.rs/doccall/bitstream/handle/123456789/3178/Referat.pdf | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:33127/bdef:Content/download | |
dc.identifier.uri | https://plus.cobiss.net/cobiss/sr/sr/bib/139117833 | |
dc.identifier.uri | https://nardus.mpn.gov.rs/handle/123456789/22316 | |
dc.description.abstract | U ovom radu je opisana sinteza, karakterizacija i biološka aktivnost novih organorutenijumskih kompleksa. Sintetisani su kompleksi koji se sastoje od benzenskog, toluenskog i cimenskog arenskog dela, a kao ligandi su korišćeni hlorhinolinski derivati, planarni aromatični polipiridini, dihidrazid i hlorido anjoni. Sintetisani su ligandi: 1-(7-hlorhinolin-4-il)tiourea, kao predstavnik 7-hlorhinolina, 11,12-dimetildipirido[3,2-a:2′,3′-c]fenazin (Me2dppz), 2-(9-antril)-1H-imidazo[4,5-f] [1,10]fenantrolin (aip) i pirido[2',3':5,6]pirazino[2,3-f][1,10]fenantrolin (ppf) koji predstavljaju seriju planarnih aromatičnih polipiridinskih liganada koji daju kompleksima lipofilna svojstva i samim tim olakšavaju prodor u ćeliju i ispoljavanje željenog dejstva i N 1 ,N 2 -dipropionilhidrazin, koji je koordinovan za dva rutenijum(II) centra dao kompleks. Svi kompleksi su okarakterisani infacrvenom i NMR spektroskopijom, masenom spektrometrijom i molekulske formule su potvrđene elementalnom analizom. Stabilnost kompleksa u rastvoru DMSO-a je takođe analizirana zbog daljih bioloških istraživanja u ovom medijumu i na osnovu NMR spektara je potvđena stabilnost kompleksa. Biološka istraživanja aktivnosti sintetisanih liganada i kompleksa su in vitro izvršena na tumorskim ćelijama: karcinoma grlića materice (HeLa), humanoj ćelijskoj liniji endotela (EA.hy 926), mijelogenoj eritroleukemiji (K562), alveolarnom bazalnom adenokarcinomu (A549), karcinomu dojke (MDA-MB-231) i jednoj netumorskoj humanoj ćelijskoj liniji fibroblasta iz pluća (MRC-5). Kompleksi su pokazali bolju aktivnost u poređenju sa ligandima, a cimenski kompleksi se mogu izdvojiti kao aktivniji u odnosu na ostale arenske komplekse. Antitumorsko dejstvo nekih jedinjenja je sličnih vrednosti aktivnosti kao cisplatina, a u nekim slučajevima su rutenijumski kompleksi pokazali i znatno veću aktivnost. | sr |
dc.description.abstract | In this is presented synthesis, characterization and biological activity of new organotrainum complexes. Complexes contain benzene, toluene and cymene as part of arene moiety, and chloroquinoline derivatives, planar aromatic polypyridines dihydrazide and chlorido anions as ligands. Synthesized ligands: 1-(7-chloroquinolin-4-yl)thiourea, as a representative of 7- chloroquinoline, potent antimalaran, 11,12-dimethyldipyrido[3,2-a:2',3'-c]phenazine (Me2dppz), 2-(anthracen-9-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip) and pyrido[2',3':5,6]pyrazino[2,3-f][1,10]phenanthroline (ppf) representing a series of planar aromatic polypyridine ligands that give complexes lipophilic properties and thus facilitate cellular uptake, and expression of the desired anticancer effect, and N 1 , N 2 -dipropionylhydrazine, which gave a complex coordinated to two ruthenium(II) centers. All complexes were characterized by infrared and NMR spectroscopy, mass spectrometry and molecular formula were confirmed by elemental analysis. The stability of the complex in the DMSO solution was also analyzed for further biological tests in this medium, and based on the NMR spectra, the stability of the complex was confirmed. Biological studies of the activity of synthetic ligands and complexes were performed in vitro on tumor cells: human cervical adenocarcinoma (HeLa), human umbilical vein endothelial cells (EA.hy 926), human myelogenous leukemia (K562), human alveolar basal adenocarcinoma (A549), human breast adenocarcinoma (MDA -MB-231) and one nontumor human lung fibroblast cell line (MRC-5). Complexes have shown better activity compared to ligands, and cymene complexes can be highlighted as the more active in relation to other arene complexes. The antitumor effect of some compounds is similar to the activity values of cisplatin, and in some cases ruthenium complexes have shown significantly higher activity. | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Београду, Хемијски факултет | sr |
dc.rights | openAccess | en |
dc.source | Универзитет у Београду | sr |
dc.subject | organorutenijumski kompleksi, hlorhinolin, interkalacija, tumor, citotoksičnost | sr |
dc.subject | organoruthenum complexes, chloroquinoline, intercalation, cancer, cytotoxicity | en |
dc.title | Sinteza i karakterizacija rutenijum-arenskih kompleksa sa N, S ili O donorskim ligandima | sr |
dc.title.alternative | Synthesis and characterization of ruthenium-arene complexes with N, S or O donor ligands | en |
dc.type | doctoralThesis | |
dc.rights.license | ARR | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/159963/Izvestaj_Komisije_15169.pdf | |
dc.identifier.fulltext | http://nardus.mpn.gov.rs/bitstream/id/159962/Disertacija_15169.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_22316 |