Antioksidativni i antiinflamatorni efekti suplementacije orasima (Juglans regia L.) na srce pacova sa metaboličkim sindromom izazvanim ishranom bogatom fruktozom
Antioxidative and antiinflamatory effects of walnut supplementation (Juglans regia L.) on rat heart with fructose-rich diet-induced metabolic syndrome
Докторанд
Bubić, MajaМентор
Živković, MajaЧланови комисије
Stanković, AleksandraBožić Nedeljković, Biljana
Korićanac, Goran
Метаподаци
Приказ свих података о дисертацијиСажетак
Povećana konzumacija fruktoze kroz industrijsku hranu doprinosi razvoju
metaboličkog sindroma (MetS). MetS prati hronična inflamacija niskog intenziteta kojoj
doprinosi oksidativni stres i aktivacija renin-angiotenzin sistema (RAS). Orasi su bogat
izvor antioksidanasa i polinezasićenih n-3 masnih kiselina koje imaju
antiinflamatorne/imunomodulatorne efekte na kardiometaboličko zdravlje, čija
molekularna osnova nije dovoljno poznata.
Konzumacija oraha (2,4 g/dan, 6 nedelja) je smanjila sistolni krvni pritisak kod
pacova na ishrani bogatoj fruktozom (10% rastvor, 15 nedelja), pokazala je protektivni
efekat na antioksidativnu osu SIRT1-FoxO3a-MnSOD/katalaza i antiinflamatorni
kapacitet srca (smanjenje AA/EPA) i promovisala antiinflamatorni profil masnih kiselina
u plazmi (smanjenje AA/EPA i AA/DHA), koji su kompromitovani fruktoznom
ishranom. Ulogu negativnih regulatora antioksidativne ose, Nox4 i ChREBP, u srcu treba
dodatno ispitati jer je nivo Nox4 povećan i nakon fruktozne ishrane i n...akon
suplementacije orasima, dok je nivo ChREBP u jedru smanjen nakon fruktozne ishrane i
nakon konzumacije oraha kod kontrolnih pacova. Fruktozna ishrana je aktivirala signalni
put koji reguliše inflamaciju povećanjem nivoa transkripcionog faktora NF-κB i ključnog
enzima RAS-a, АСЕ, dok je suplementacija orasima kod pacova na fruktoznoj ishrani
povećala nivo ACE2, kardioprotektivne komponente RAS-a. Na proteinski/iRNK nivo
RAS receptora, AT1R i AT2R, nije uticao nijedan od dva nutritivna faktora.
Ova studija je potvrdila korisne efekte konzumacije oraha na kardiometabolički
status i predloţila mehanizme koji su u osnovi njihovih antiinflamatornih i
antioksidativnih efekata u srcu, ukazujući na mogućnost razvoja novih, nefarmakoloških
pristupa u terapiji kardiometaboličkih bolesti.
Increased fructose intake via industrial food is associated with metabolic syndrome
(MetS). MetS is characterized by chronic low-intensity inflammation caused by oxidative
stress and activation of the renin-angiotensin system (RAS). Walnuts are a rich source of
antioxidants and polyunsaturated n-3 fatty acids that exert anti-
inflammatory/immunomodulatory effects on cardiometabolic health, which molecular
background is underexplored.
Walnut consumption (2.4 g/day, 6 weeks) reduced systolic blood pressure in rats
fed a fructose-rich diet (10% FRD, 15 weeks), showed a protective effect on the
antioxidative axis SIRT1-FoxO3a-MnSOD/catalase and anti-inflammatory cardiac capacity
(AA/EPA reduction) and promoted the anti-inflammatory profile of plasma fatty acids
(AA/EPA and AA/DHA reduction), which were compromised by FRD. The role of the
axis negative regulators, Nox4 and ChREBP, should be further investigated in the heart
because the Nox4 level was increased by both, FRD and walnut supple...mentation, while
the ChREBP nuclear level was reduced in FRD as well as in control rats subjected to
walnuts. FRD activated a signaling pathway that regulated inflammation by increasing the
levels of the transcription factor NF-κB and the key RAS enzyme, ACE, while walnut
supplementation in FRD rats increased ACE2 level, a cardioprotective component of the
RAS. The protein/mRNA levels of the RAS receptors, AT1R and AT2R, were not affected
by either of the two nutritional factors.
This study confirmed the beneficial effects of walnut consumption on
cardiometabolic status and proposed the mechanisms underlying their anti-inflammatory
and antioxidative effects in the heart, indicating the possibility for development of novel,
non-pharmacological approaches in cardiometabolic disease therapy.