Povezanost oksidacionog stresa i periapikalnih lezija kod hipertenzivnih pacova
Association of oxidative stress and periapical lesions in hypertensive rats
Author
Milojević, AndjelaMentor
Živković, VladimirCommittee members
Vasović, MiroslavJakovljević, Vladimir
Milosavljević, Marko
Mališ, Miloš
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Show full item recordAbstract
Cilj ove studije je bio da ispita povezanost periapikalnih lezija, funkcije srca i
oksidacionog stresa kod pacova u uslovima hipertenzije i normotenzije.
Istraživanje je obuhvatilo 48 pacova Wistar soja, svrstanih u 4 eksperimentalne
grupe: I-kontrola, II-normotenzivni pacovi sa prisustvom periapikalnih lezija, IIIspontanohipertenzivni pacovi bez prisustva periapikalnih lezija, IVspontanohipertenzivni pacovi sa prisustvom periapikalnih lezija. Uzorci tkiva
hemimandibula korišćeni su za patohistološku, histomorfometrijsku analizu i
isptivanje koncentracije proinflamatornih citokina. Određivani su markeri
sistemskog i srčanog oksidacionog statusa. Icpitivan je uticaj lezija na promenu
funkcije izolovanog srca pacova metodom retrogradne perfuzije po Langendorff-u. Sa
patohistološkog i histomorfometrijskog aspekta, debljina periodontalnog
ligamenta, resorpcija alveolarne kosti i apikalnog cementa, intezitet i
ekstenzivnost periapikalnog inflamatornog infiltrata bila je značajno veća u grup...i
hipertenzivnih pacova. Koncentracija većine proinflamatornih citokina lezija
bila je viša u hipertenzivnim stanjima. Periapikalne lezije bile su povezane sa
poremećenom kardiodinamikom i patohistološkim promenama izolovanih srca
pacova u hipertenzivnim uslovima. Takođe, bile su u korelaciji sa povećanim
vrednostima prooksidanasa i manjom mobilnošću antioksidanasa posebno u
hipertenzivnom stanju. Uopšeno posmatrano, periapikalne lezije i hipertenzija
međusobno su povezane na ispitivanom modelu pacova. Sadašnji rezultati mogu
pomoći boljem razumevanju povezanosti periapikalnih lezija i srčane funkcije u
hipertenzivnim uslovima, podržavajući pretpostavku da lezije mogu negativno
uticati na funkciju srca i potencijalno poremetiti homeostazu oksidacionog statusa
u eksperimentalnom modelu pacova.
The aim of this study was to investigate the link between periapical lesion, cardiac function
and oxidative stress in rats under conditions of hypertension and normotension. The study
included 48 Wistar rats, divided into 4 experimental groups: I-control, II-normotensive rats
with periapical lesions, III-spontaneously hypertensive rats without periapical lesions, IVspontaneously hypertensive rats with periapical lesions. Hemimandibular tissue samples were
used for histopathological, histomorphometric analysis and examination of the concentration
of proinflammatory cytokines. Markers of systemic and cardiac oxidative status were
determined. The influence of lesions on the change of function of isolated rat hearts by the
method of retrograde perfusion according to the Langendorff technique was examined. From
the pathohistological and histomorphometric aspects, periodontal ligament thickness, alveolar
bone and apical cementum resorption, intensity and extension of inflammatory infiltrate ...were
significantly higher in the hypertensive rats. The concentration of most proinflammatory
cytokines in lesions was significantly higher in hypertensive conditions. Periapical lesions
were associated with impaired cardiodynamics and pathohistological changes on isolated rat
hearts in hypertensive conditions. Also, they were correlated with increased values of
prooxidants and decreased mobility of antioxidants in a hypertensive state. In general,
periapical lesions and hypertension were correlated in a rat model. Results may help to better
understand the association between lesions and cardiac function in hypertensive conditions,
supporting the hypothesis that lesions may adversely affect cardiac function and potentially
disrupt oxidative status homeostasis in an experimental rat model.