Nova biološki aktivna sintetska azaheterociklična jedinjenja i novi sekundarni metaboliti iz odabranih biljnih vrsta: sinteza, izolovanje i spektralna karakterizacija
Докторанд
Zlatković, Dragan B.Ментор
Radulović, NikoЧланови комисије
Popsavin, MirjanaDekić, Vidoslav
Ilić-Tomić, Tatjana
Ranđelović, Pavle
Метаподаци
Приказ свих података о дисертацијиСажетак
The aim of this PhD thesis was the discovery of new biologically active
compounds either by means of natural product isolation from selected plant
taxa or by organic synthesis. All of the either isolated or synthesized
compounds were characterized by spectroscopic methods, including one- and
two-dimensional NMR experiments. The specific compounds that were the
subject of this research were: aromatic esters from Ferula ovina (Apiaceae),
octyl esters from Heracleum sphondylium (Apiaceae), diesters of an
oxygenated germacrane derivative from Daucus carota (Apiaceae),
isothiocyanates from Reseda lutea (Resedaceae) and germacrone epoxides
from Geranium macrorrhizum (Geraniaceae). Also, as a part of this
dissertation, a synthesis of new ferrocene-indole hybrids and the investigation
of complex metal hydride reduction of Biginelli compounds was performed.
A number of these compounds were tested for their biological activities
(antimicrobial, cytotoxic, antinociceptive and antiace...tylcholinesterase
activities).
Факултет:
Универзитет у Нишу, Природно-математички факултетДатум одбране:
18-02-2019Пројекти:
- Science in Motion for Friday Night Commotion (EU-FP7-316471)
- Комбинаторне библиотеке хетерогених катализатора, природних производа, модификованих природних производа и њихових аналога: пут ка новим биолошки активним агенсима (RS-MESTD-Basic Research (BR or ON)-172061)