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Quality of life assessment in women of reproductive age treated for pathological changes in the uterine cervix

dc.contributor.advisorKesić, Vesna
dc.contributor.otherPekmezović, Tatjana
dc.contributor.otherSpremović Rađenović, Svetlana
dc.contributor.otherKisić Tepavčević, Darija
dc.contributor.otherRadojčić, Ljiljana
dc.creatorSparić, Radmila M.
dc.date.accessioned2018-09-17T11:44:44Z
dc.date.available2018-09-17T11:44:44Z
dc.date.issued2018-06-13
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=5978
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:18184/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50412047
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/9862
dc.description.abstractUčestalost pojave displazije grlića materice pokazuje porast, naročito kod žena u reproduktivnom periodu. Pravovremeno lečenje ovih promena je značajno za smanjenje učestalosti pojave invazivnog karcinoma grlića materice, a ispitivanje kvaliteta života povezanog sa zdravljem (HRQoL) nakon lečenja displazije doprinosi unapređenju ishoda lečenja. I pored toga, u kliničkoj praksi kod nas nisu zaživeli adekvatni instrumenti za ispitivanje HRQoL ovih žena. Pored same bolesti i njenog hirurškog lečenja, na HRQoL žena u reproduktivnom periodu hirurški lečenih zbog patoloških promena grlića materice mogu uticati i dugoročne posledice lečenja na reproduktivnu funkciju, mogući infertilitet i povišen rizik perinatalnog morbiditeta i mortaliteta. Pored toga, lečenje može dovesti do značajnih promena u psihičkoj sferi i seksualnosti. Ciljevi: Primarni cilj istraživanja bila je psihometrijska validacija srpske verzije instrumenta za ispitivanje HRQoL žena sa cervikalnom displazijom FACIT-CD (Functional Assessment of Chronic Ilness Therapy-Cervical Dyplasia). Drugi cilj bilo je ispitivanje HRQoL žena u reproduktivnom periodu lečenih ekscizionim hirurškim metodama zbog skvamozne intraepitelne lezije (SIL) FACIT-CD upitnikom, SF-36v2 upitnikom, Bekovim upitnikom za anksioznost (BAI) i Bekovim upitnikom za depresiju (BDI), posebno u odnosu na reproduktivne karakteristike ispitanica: paritet i zainteresovanost za reprodukciju. Pacijenti i metode: Istraživanje je sprovedeno kao studija preseka i obuhvatilo je žene operisane iz dijagnostičkih ili terapijskih razloga dve i više godina pre uključivanja u studiju, kod kojih je histološki potvrđeno postojanje SIL. Kriterijumi za isključivanje iz studije bili su postojanje invazivne promene grlića, naknadni tretman grlića, kao i postojanje drugih patoloških promena na genitalnim organima i/ili hroničnih oboljenja koja mogu remetiti HRQoL. Prikupljeni su sociodemografski i klinički podaci ispitanica, a HRQoL je procenjivan FACIT-CD, SF-36v2, BAI i BDI upitnicima. Rezultati: Srpska verzija FACIT-CD upitnika je pokazala zadovoljavajuće psihometrijske karakteristike...sr
dc.description.abstractThe incidence of cervical dysplasia is growing, particularly in women of reproductive age. Timely treatment of these changes is important for reducing the incidence of invasive cervical cancer, and the investigation of health related quality of life (HRQoL) following dysplasia treatment contributes to a better treatment outcome. Nevertheless, adequate instruments for studying HRQoL in women are still not widely used in our clinical practice. Apart from the disease itself and its surgical treatment, the HRQoL in women of reproductive age that were surgically treated can be influenced by the long-term consequences of the treatment on the reproductive function, possible infertility, and increased risk of perinatal morbidity and mortality. Moreover, treatment may lead to significant changes in the psychological field and in sexuality. Aims: The primary aim of our research was psychometric validation of the Serbian version of the HRQoL assessment instrument for women with cervical dysplasia - FACIT-CD (Functional Assessment of Chronic Illness Therapy-Cervical Dysplasia). The secondary aim was the evaluation of the HRQoL in women of reproductive age treated by excisional surgical methods for squamous intraepithelial lesion (SIL), using the FACIT-CD questionnaire, the SF-36v2 questionnaire, the Beck’s anxiety inventory (BAI), and the Beck’s depression inventory (BDI), particularly in relation to the reproductive characteristics of the participants: parity and fertility interest. Patients and methods: Research was conducted as a cross-sectional study, and it encompassed women operated for diagnostic or therapeutic reasons two and more years prior to study enrollment, in whom SIL was histologically confirmed. The exclusion criteria were: the presence of invasive disease, repeated cervical treatment, the presence of other pathological changes on the reproductive organs and/or chronic diseases that could impair the HRQoL. The data on socio-demographic and clinical characteristics of the participants were collected, and the HRQoL was assessed using the FACIT-CD, SF-36v2, BAI and BDI questionnaires...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsAutorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
dc.sourceУниверзитет у Београдуsr
dc.subjectcervikalna displazijasr
dc.subjectcervical dysplasiaen
dc.subjecthealth related quality of lifeen
dc.subjectquestionnaireen
dc.subjectpsychometric validationen
dc.subjectparityen
dc.subjectreproductionen
dc.subjectkvalitet života povezan sa zdravljemsr
dc.subjectupitniksr
dc.subjectpsihometrijska validacijasr
dc.subjectparitetsr
dc.subjectreprodukcijasr
dc.titleProcena kvaliteta života kod žena u reproduktivnom periodu lečenih zbog patoloških promena grlića matericesr
dc.title.alternativeQuality of life assessment in women of reproductive age treated for pathological changes in the uterine cervixen
dc.typePhD thesis
dcterms.abstractКесић, Весна; Радојчић, Љиљана; Кисић Тепавчевић, Дарија; Пекмезовић, Татјана; Спремовић Рађеновић, Светлана; Спарић, Радмила М.; Процена квалитета живота код жена у репродуктивном периоду лечених због патолошких промена грлића материце; Процена квалитета живота код жена у репродуктивном периоду лечених због патолошких промена грлића материце;


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