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Analysis of micrometastatic lymphogenic propagation of colorectal carcinoma metastases

dc.contributor.advisorKaramarković, Aleksandar
dc.contributor.otherMicev, Marjan
dc.contributor.otherKnežević, Srbislav
dc.contributor.otherOprić, Dejan
dc.contributor.otherDarković, Mirko
dc.creatorBasarić, Dragan D.
dc.date.accessioned2018-09-12T08:46:41Z
dc.date.available2018-09-12T08:46:41Z
dc.date.available2020-07-03T08:45:51Z
dc.date.issued2018-06-11
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=5943
dc.identifier.urihttp://nardus.mpn.gov.rs/handle/123456789/9832
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:18106/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50364175
dc.description.abstractCilj: Ispitati učestalost i distribuciju mikrometastatskih limfnih nodusa hepatičnog sliva i prognostički značaj rutinske regionalne limfadenektomije s posebnim osvrtom na pojavu recidiva maligne bolesti. Metod: Ukupno 50 bolesnika sa metastatskom bolesti jetre podvrgnuto je resekciji jetre sa rutinskom limfadenektomijom. Rezultati: Pozitivni limfni nodusi hepatičnog sliva prisutni su kod 14 bolesnika (28%) bolesnika. Standardna H&E patohistološka analiza verifikuje 6 bolesnika (12%) sa pozitivnim limfnim nodusima hepatičnog sliva. Imunohistohemijska analiza dodatno verifikuje još 8 bolesnika (16%) pozitivnih limfnih nodusa hepatičnog sliva preostalih limfnih nodusa. Limfni nodusi duž zajedničke hepatične arterije (grupa 8a i 8p) najčešće sadrže mikrometastaze kolorektalnog karcinoma (53,84%, i 19,23%). MSCT trbuha je od koristi za preoperativnu dijagnostiku limfadenopatije (18,42%). Slobodni interval do pojeve metastaza je u proseku 15 meseci. Recidiv maligne bolesti javio se kod 38,0% bolesnika. Volumen metastatske bolesti jetre značajan faktor recidiva maligne bolesti (p<0,05) Zaključak: Rutinska limfadenektomija hepatičnog sliva je bezbedna i preporučljiva procedura u prevenciji širenja kolorektalne metastatske bolesti, koja neznatno povećava vreme trajanja operacije u celini (prosečno 32 minuta) i ne povećava učestalost postoperativnih komplikacija.sr
dc.description.abstractObjective: To investigate the frequency and distribution of micrometastatic lymph nodus of the hepatic basin and the prognostic significance of routine regional lymphadenectomy with particular reference to the occurrence of relapse of malignant disease. Methods: A total of 50 patients with metastatic liver disease underwent resection of the liver with routine lymphadenectomy. Results: Positive lymph nodes of the hepatic basin are present in 14 patients (28%) of patients. The standard H & E pathohistological analysis verifies 6 patients (12%) with positive lymph nodes of the hepatic basin. Immunohistochemical analysis further verified another 8 patients (16%) of positive lymph nodes of the hepatic basin of the remaining lymph nodes. Lymph nodes along the common hepatic artery (group 8a and 8p) most commonly contain colorectal carcinoma micrometastases (53.84%, and 19.23%). MDCT abdomen is beneficial for preoperative diagnosis of lymphadenopathy (18.42%). The free interval to metastasis rates is on average 15 months. The recurrence of malignancy occurred in 38.0% of patients. The volume of metastatic liver disease is an important factor of relapse of malignant disease (p <0.05). Conclusion: Routine lymphadenectomy of the hepatic basin is a safe and recommended procedure in the prevention of the spread of colorectal metastatic disease, which slightly increases the duration of the operation as a whole (an average of 32 minutes) and does not increase the incidence of postoperative complications.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsopenAccessen
dc.sourceУниверзитет у Београдуsr
dc.subjectrutinska limfadenektomijasr
dc.subjectroutine lymphadenectomyen
dc.subjecthepatic basinen
dc.subjectmetastatic disease of colorectal canceren
dc.subjectresection of the liveren
dc.subjectpostoperative complicationsen
dc.subjectrelapse of malignant disease.en
dc.subjecthepatični slivsr
dc.subjectmetastatska bolest kolorektalnog karcinomasr
dc.subjectresekcije jetresr
dc.subjectpostoperativne komplikacijesr
dc.subjectrecidiv maligne bolestisr
dc.titleAnaliza mikrometastatske limfogene propagacije karcinomskih ćelija jetre kolorektalnog poreklasr
dc.title.alternativeAnalysis of micrometastatic lymphogenic propagation of colorectal carcinoma metastasesen
dc.typedoctoralThesis
dc.rights.licenseBY-NC
dcterms.abstractКарамарковић, Aлександар; Мицев, Марјан; Кнежевић, Србислав; Опрић, Дејан; Дарковић, Мирко; Басарић, Драган Д.; Aнализа микрометастатске лимфогене пропагације карциномских ћелија јетре колоректалног порекла; Aнализа микрометастатске лимфогене пропагације карциномских ћелија јетре колоректалног порекла;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/8134/IzvestajKomisije17509.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/8133/Disertacija.pdf


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