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The interaction of bipyridyl gold(III) complexes and polyoxotungstates with Na+/K+-ATPaze and acetylcholinesterase

dc.contributor.advisorPopović-Bijelić, Ana
dc.contributor.otherVasić, Vesna
dc.contributor.otherMojović, Miloš
dc.contributor.otherČolović, Mirjana
dc.creatorBondžić, Aleksandra
dc.date.accessioned2017-12-12T15:45:16Z
dc.date.available2017-12-12T15:45:16Z
dc.date.issued2017-11-03
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=5415
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:16789/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49630735
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/8943
dc.description.abstractU ovoj doktorskoj disertaciji ispitan je uticaj antitumorskih mononuklearnih i binuklearnih kompleksa zlata(III) (AubipyC, Aubipy(OH)2, Aupy(OAc)2, Auoxo6, Au2bipyC i Au2phen) na Na+/K+-ATPazu, kao i uticaj polioksometalata, 12- volframsilicijumove i 12-volframfosforne kiseline (WSiA i WPA) na acetilholinesterazu (AChE). Primenom različitih fizičkohemijskih metoda (UV/Vis i fluorescentna spektroskopija, cirkularni dihroizam, elektronska paramagnetna rezonantna (EPR) spektroskopija) u kombinaciji sa molekulskim modelovanjem, dobijen je detaljan uvid u njihovu interakciju na molekulskom nivou. Ispitivanjem uticaja ovih jedinjenja na antioksidativne enzime i na nivo malondialdehida, procenjeni su njihovi toksični potencijali, a merenjem učestalosti mikronukleusa i indeksa ćelijske proliferacije procenjeni su njihovi genotoksični i citotoksični efekti...sr
dc.description.abstractIn this doctoral dissertation, the interaction of antitumor mononuclear and binuclear gold(III) complexes (AubipyC, Aubipy(OH)2, Aupy(OAc)2, Auoxo6, Au2bipyC and Au2phen) with Na+/K+-ATPas,e as well as the interaction of polioxotungstates, 12- tungstosilicic acid and 12-tungstophosphoric acid (WSiA and WPA), with acetylholinesterase have been investigated. Various spectroscopic methods (UV/Vis and fluorescent spectroscopy, circular dichroism, electron paramagnetic resonance (EPR) spectroscopy) in combination with docking studies were used in order to obtain detailed insight into their interaction on the molecular level. By investigating the influence of these compounds on the antioxidative enzymes and the level of malondialdehyde, their toxic potentials were evaluated. Furthermore, their genotoxic and cytotoxic effects were estimated by measuring the incidence of micronuclei and the cytokinesis-block proliferation index in human lymphocyte cultures...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Факултет за физичку хемијуsr
dc.rightsAutorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
dc.sourceУниверзитет у Београдуsr
dc.subjectkompleksi zlata, Na+/K+-ATPaza, polioksovolframati, acetilholinesteraza, fluorescentna spektroskopija, cirkularni dihroizam, EPR spektroskopija, oksidativni stres, genotoksičnost, citotoksičnostsr
dc.subjectgold complexes, Na+/K+-ATPase, polioxotungstates, acetylholinesterase, fluorescent spectroscopy, circular dichroism, EPR spectroscopy, oxidative stress, genotoxicity, citotoxicityen
dc.titleInterakcija bipiridinskih kompleksa zlata(III) i polioksovolframata sa Na+/K+-ATPazom i acetilholinesterazomsr
dc.title.alternativeThe interaction of bipyridyl gold(III) complexes and polyoxotungstates with Na+/K+-ATPaze and acetylcholinesteraseen
dc.typePhD thesis


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