Kombinatorne biblioteke odabranih prirodnih i sintetskih biološki aktivnih estara
Mladenović, Marko Z.
Faculty:Универзитет у Нишу, Природно-математички факултет
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Herein, a successful identification and a means of arriving at (milli)gram quantities of the selected natural esters was achieved through the application of a synthetic combinatorial approach (three libraries with 171 constituents in total, among them 121 new compounds). As a result, new secondary metabolites from Achillea falcata L. ((1R*,3S*,5R*)-sabinyl formate and tiglate), Achillea ageratifolia (Sm.) Boiss. subsp. serbica (Nyman) Heimerl ((1R*,3S*,5R*)-sabinyl formate, tiglate, nonanoate and decanoate), Scandix balansae Reut. ex Boiss. (octadecyl valerate), Scandix pecten-veneris L. (esters of isobutanoic acid and n-C15, C17, C21 and C23 alkanols, as well as esters of isovaleric acid and n-C13, C15 and C17 alkanols) and Anthemis segetalis Ten. (eugenyl angelate, 2-methylbutanoate and 3- methylbutanoate) essential-oil samples wеre identified. Also, the combinatorial approach was successful used for a systematical comparison of chemical/biological properties of ferrocene-containing
esters and their corresponding phenyl analogs (a library of eighteen (13 new) 2-substituted methyl acetoacetates). The structures of the synthesized esters were spectrally characterized by MS, NMR (1D- and 2D-NMR, as well as, an NMR methodology that employ lanthanide-induced shifts), FTIR and UV-Vis analyses, and in the case of ferrocene-containing compounds by electrochemical (cyclic voltammetry) and X-ray analyse(s). Several esters were shown to be toxic to A. salina, possessed cytotoxic (to two cell lines), AChE inhibitory, antinociceptive and antimicrobial activities. Antinociceptive activity of (1R*,3S*,5R*)-sabinol was two times higher than that of morphine, and the antifungal activity of 2- acetyl-2-(ferrocenylmethyl)-4-methyl-4-pentenoate was comparable to that of nystatin against Candida albicans.View More
Keywords:Organska sinteza; Organic synthesis; combinatorial libraries of esters; (1R*; 3S*; 5R*)-sabinol; longchain alkanols; regioisomeric allylmethoxyphenols; methyl-2-benzylacetoacetates; methyl-2-(ferrocenylmethyl)acetoacetates; essential oils; biological/pharmacological activity; QSPR; kombinatorne biblioteke estara; etarska ulja; (1R*; 3S*; 5R*)-sabinol; dugolančani alkoholi; regioizomerni alilmetoksifenoli; metil-2-(ferocenilmetil)acetoacetati; metil-2- benzilacetoacetati; biološka/farmakološka aktivnost; QSPR