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dc.contributor.advisorŠmelcerović, Andrija
dc.contributor.otherAgbaba, Danica
dc.contributor.otherNajman, Stevo
dc.contributor.otherKocić, Gordana
dc.contributor.otherArsić, Ivana
dc.creatorStojanović, Igor Ž.
dc.date.accessioned2017-07-24T08:19:23Z
dc.date.available2017-07-24T08:19:23Z
dc.date.issued2017-06-09
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=5136
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:1382/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=533898134
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/8418
dc.descriptionThe objectives of the doctoral dissertation were achieved by determining the chemical composition of the extracts of H. physodes, isolation, structural determination and testing of the biological activity of physodalic acid, physodic acid, 3-hydroxyphysodic acid and atranorin. In this dissertation antioxidant activity, cytotoxic activity on cells of human cervix carcinoma and on rat thymocytes, anticholinesterase activity, antimicrobial activity and influence on the formation of micronuclei in lymphocytes of human blood plasma of physodalic acid, physodic acid, 3-hydroxyphysodic acid and atranorin were investigated The antioxidant activity and anticholinesterase activity were investigated by spectrophotometric methods. Cytotoxic activity on cells of human cervix carcinoma and rat thymocytes was assayed by a colorimetric MTT assay, and CCK-8 assay, respectively. The impact on the formation of micronuclei in lymphocytes of human blood plasma was investigated by micronucleus test. Antimicrobial activity was tested by using microdilution method. Comparing the literature available to us, and these results, it was found that for the first time was investigating the effect of Hypogymnia physodes methanol extract on cells of human cervical cancer and the number of micronuclei in lymphocytes of human blood plasma, impact of atranorin on the number of micronuclei in lymphocytes of human blood plasma and serum activity cholinesterase, antioxidant activity of 3-hydroxyphysodic acid and its effects on rat thymocytes, the number of micronuclei in lymphocytes of human blood plasma, the cells of the human cervical cancer and the activity of serum cholinesterase and the impact physodic acid on rat thymocytes, the number of micronuclei in human lymphocytes blood plasma, the cells of the human cervical cancer and serum cholinesterase activity and antioxidant activity of physodalic acid and its effect on rat thymocytes, the number of micronuclei in lymphocytes of human blood plasma, the cells of the human cervical cancer and the activity of serum cholinesterase. 3-Hydroxyphysodic acid shows a greater anti-oxidant activity from a commercial antioxidant 3,5-di-tert-butyl-4-hydroxytoluene (BHT), and reduce the number of micronucleus cells in human blood plasma 2.2 times more than the commercial protectant amifostine, recommending it as good candidate for in vivo experiments.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Медицински факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172044/RS//
dc.rightsAutorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
dc.sourceУниверзитет у Нишуsr
dc.subjectHypogymnia physodes; fizodalična kiselina; fizodična kiselina; 3-hidroksifizodična kiselina; atranorin; antioksidantna aktivnost; citotoksična aktivnost; antiholinesterazna aktivnost; mikronukleusni test; antimikrobna aktivnostsr
dc.subjectHypogymnia physodes; physodalic acid; physodic acid; 3-hydroxyphysodic acid; atranorin; antioxidant activity; citotoxic activity; anticholinesterase activity; micronucleus test; antimicrobial activityen
dc.titleBiološka aktivnost depsidona i atranorina izolovanih iz lišaja Hypogymnia physodessr
dc.typePhD thesis
dcterms.abstractШмелцеровић, Aндрија; Најман, Стево; Коцић, Гордана; Aрсић, Ивана; Aгбаба, Даница; Стојановић, Игор Ж.;


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