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Helicobacter pylori in dental plaque in patients with gastric and duodenal disease

dc.contributor.advisorTeodorović, Nevenka
dc.contributor.otherKaradžić, Branislav
dc.contributor.otherBrmbolić, Branko
dc.contributor.otherRanin, Lazar
dc.creatorLatković, Marina B.
dc.date.accessioned2017-02-27T10:10:08Z
dc.date.available2017-02-27T10:10:08Z
dc.date.issued2016-09-27
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=4588
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:14702/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48701199
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/7641
dc.description.abstractOtkrićem bakterije Helicobacter pylori (H. pylori) 1982. godine (Warren i Marshal), počinje novo istorijsko razdoblje u gastroenterologiji. Otkriće ove gram negativne bakterije dovelo je do revolucije patogeneze ulkusne bolesti, karcinoma i primarnog limfoma želuca niskog stepena malignosti (MALT-limfom), te lečenja ulkusne bolest. Literaturni podaci o istovremenoj kolonizaciji H. pylori u dentalnom plaku i sluzokoži želuca kod pacijenata sa gastričnim smetnjama su vrlo kontradiktorni. Uzimajući u obzir rasprostranjenost H. pylori infekcije, rastuću otpornost na terapiju, kao i postojanje potencijalnih rezervora unutar usne duplje, značaj razumevanja odnosa između bakterija koje naseljavaju želudac i onih u dentalnom plaku se sam nameće. Uticaj stomatologa na mogućnosti prevencije i terapije je veoma značajan, a sa druge strane nedovoljno istražen. Osnovni cilj ove doktorske disertacije je bio određivanje korelacije nalaza H. pylori u želucu i H. pylori u dentalnom plaku u pacijenata sa tegobama koje se odnose na gornji deo digestivnog trakta kao i korelacije istih nalaza nakon primenjene terapije kod pacijenata kod kojih je potvrđeno prisustvo H. pylori u želucu. Istraživanje je dizajnirano kao prospektivna studija. U studiji je učestvovalo 158 pacijenata podeljenih u dve grupe. Prvu ciljnu grupu činilo je 118 pacijenata sa tegobama koje se odnose na gornji deo digestivnog trakta i u kojih je bila indikovana endoskopska dijagnostika radi identifikacije H. pylori. Drugu kontrolnu grupu činilo je 40 pacijenata koji nisu imali nikakve tegobe vezane za gornji deo digestivnog trakta. Pacijentima ciljne grupe, podvrgnutim ezofagogastroduodenoskopiji, uzimani su isečci želudačne sluznice za patohistološku analizu, brzi ureaza test i bakterijsku kulturu. Neposredno pred ezofagogastroduodenoskopiju određivan je indeks dentalnog plaka...sr
dc.description.abstractThe discovery of Helicobacter pylori (H. pylori) bacteria in 1982 (by Warren and Marshall) begins a new historical era in gastroenterology. Discovery of gramnegative bacteria has led to the revolution of the pathogenesis of ulcer disease, cancer alone, primary gastric lymphoma low-grade malignancy (MALT - lymphoma), and treatment of ulcer disease. Literature data on colonisation of H. pylori in dental plaque and in gastric mucosa at the same time in patients with gastric disorders are contradictory. Taking into account the prevalence of H. pylori infections, increasing resistance to therapy, and the potential existence of a reservoir within the oral cavity, the importance of understanding the relationship between the bacteria that inhabit the stomach and those in dental plaque imposes itself. The impact of dentists on the possibilities of prevention and treatment is very important, but on the other hand insufficiently explored. The main objective of this doctoral thesis was to determine the correlation of findings of H. pylori in the stomach and H. pylori in dental plaque in patients with disorders related to the upper part of the digestive tract as well as the correlation of these findings after the applied therapy in patients with confirmed presence of H. pylori in the stomach. The study was designed as a prospective study. The study comprised 158 patients divided into two groups. The first, target, group consisted of 118 patients with problems related to the upper part of the digestive tract and in which endoscopic diagnostics was indicated for identification of H. pylori. The second, control, group consisted of 40 patients who did not have any problems related to the upper part of the digestive tract. In the target group patients were subjected to esophagogastroduodenoscopy, and cuts of gastric mucosa were taken for histopathological analysis, rapid urease test and culture of bacteria...en
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dc.languagesr
dc.publisherУниверзитет у Београду, Стоматолошки факултетsr
dc.rightsAutorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
dc.sourceУниверзитет у Београдуsr
dc.subjectHelicobacter pylori, ezofagogastroduodenoskopija, patohistološki nalaz, dentalni plak, ureaza test, bakterijska kulturasr
dc.subjectHelicobacter pylori, esophagogastroduodenoscopy, histopathologic findings, dental plaque, urease test, culture of bacteriaen
dc.titleHeliobacter pylori u dentalnom plaku kod pacijenata sa oboljenjem želuca i duodenumasr
dc.title.alternativeHelicobacter pylori in dental plaque in patients with gastric and duodenal diseaseen
dc.typePhD thesis
dcterms.abstractТеодоровић, Невенка; Караджић, Бранислав; Ранин, Лазар; Брмболић, Бранко; Латковић, Марина Б.;


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