Značaj analize varijabilnosti krvnog pritiska u proceni hipertrofije leve komore u dece

Abstract

Systemic arterial hypertension (HAT) is a very important risk factor for cardiovascular disease (CVD) in both adults and children. A large number of epidemiological studies clearly indicate that the majority of adult patients with high blood pressure recruited in childhood. Thanks to the implementation of 24-hour ambulatory blood pressure monitoring in everyday clinical practice researcher as well as practitioners has much better insight into the physiological or pathophysiological variations of blood pressure during the day. Clinical assessment of high blood pressure variability (BPV) in children in the context of his independent and isolated effect on the occurrence of subclinical organ damage is still not clear enough. Up to date there are no literature data concerning the importance of BPV in the development of left ventricular hypertrophy (LVH) in children. The aim of this thesis was to investigate the potential link between blood pressure variability during 24-h ambulatory monitoring and (LVH) in children with and without systemic hypertension. The results of our study will primarily answer the question of whether the most frequently used BPV parameters analyzing such as standard deviation (SD) and the average real variability (ARV) have predictive value in assessing the risk of left ventricular hypertrophy in children with systemic arterial hypertension.