Povezanost pojedinih pripadnika familije herpesvirida i parodontopatogenih mikroorganizama sa komplikacijama parodontopatije
Relationship between certain members of the family herpesviridae and paropathogenic microorganism with compilcations of periodontal disease
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Parodontopatija je hronično inflamatorno oboljenje uzrokovano malom grupom
uglavnom anaerobnih Gram-negativnih bakterija, u kom dolazi do destrukcije svih
tkiva parodoncijuma. Iako su bakterije esencijalne one nisu dovoljne da dovedu do
razvoja bolesti. Noviji podaci ukazuju na značaj virusa u patogenezi parodontopatije.
Infekcija dovodi do inflamatorne destrukcije svih tkiva parodoncijuma.
Oralni anaerobni mikroorganizmi i njihovi produkti, kao što je lipopolisaharid (LPS)
prisutni u subgingivalnom dentalnom plaku, prodorom u vezivno tkivo gingive
dospevaju u sistemsku cirkulaciju kroz ulcerisan i diskontinuiran epitel parodontalnog
džepa. Trenutno, veruje se da je patogeneza nekih tipova parodontopatije proces od više
koraka, uključujući složenu interakciju između domaćina, bakterija, virusa i raznih
faktora okoline.
Polazna hipoteza : za nastanak parodontopatije bakterije jesu esencijalne ali ne i
dovoljne da dovedu do razvoja bolesti, herpes virusi, EBV i CMV mogu dati odgovore
na ...neka otvorena pitanja vezana za mehanizam degradacije parodontalnih tkiva kao i
posledičnih komplikacija.
Ciljevi istraživanja :
1. Ispitati kvantitativno-kvalitativnu zastupljenost specifičnog bakterijskog
genoma (Porphyromonas gingivalis (P.g), Tannerella forsythensis (T.f),
Prevotella intermedia (P.i) i Aggregatibacter actinomycetemcomitans (A.g) kod
komplikacija parodontopatije (ulcero- nekrozna parodontopatija i parodontalni
apsces).
2. Ispitati kvantitativno-kvalitativnu zastupljenost specifičnog virusnog genoma
Epštajn Barov virus (EBV), Humani Citomegalovirus (HCMV) i herpes
simplex virus tip 1 (HSV-1) kod komplikacija parodontopatije (ulceronekrozna
parodontopatija i parodontalni apsces)...
Periodontal disease is a chronic inflammatory disease caused by a small group of
mainly anaerobic gram-negative bacteria, which leads to the destruction of all tissues of
periodontium. Although bacterias are essential they are not enough to lead to the
development of disease. Recent data indicate the importance of viruses in the
pathogenesis of periodontal disease.
The infection leads to inflammatory destruction of periodontal tissues.
Oral anaerobic microorganisms and their products, such as lipopolysaccharide (LPS)
present in subgingival dental plaque, penetrating into the connective tissue of the
gingiva due in systemic circulation through ulcerated and discontinuous epithelium of
the periodontal pocket.
Currently, it is believed that the pathogenesis of some types of periodontal disease
process of multiple steps including the complex interaction between the host, bacteria,
viruses, and various environmental factors.
The starting hypothesis: for the formation of periodontal bacteria..., essential, but not
sufficient to lead to the development of the disease, herpes viruses, EBV and CMV may
provide answers to some open questions related to the mechanism of degradation of
periodontal tissues as well as the consequent complications.
Objectives:
1. Identifying presence of specific bacterial flora:
Porphyromonas gingivalis(Pg), Tannerella forsythensis(Tf), Prevotella intermedi (Pi)
and Aggregatibacter actinomycetemcomitans(A.g).
2. Detection of herpes viridae family members:
Epstein Barr virus(EBV), human cytomegalovirus(HCMV) and herpes simplex
virus type 1(HSV-1) with complications of periodontal disease (periodontitis and
necrotizing ulcer-periodontal abscess)...