|dc.description.abstract||Benign biliary obstruction (BBO) is the most common group of biliary disorders,
following gallbladder calculosis. Interrupted or reduced bile flow into the duodenum,
especially long-term, induces mechanic obstructive syndrome with all its consequences
(primarily cholestasis) that requires prompt treatment (surgical or endoscopic).
Regardless of the significance and opportunities of endoscopic treatment, it is still
applicable in limited number of indications in only 15-25% of BBO patients.
BBO surgery is very versatile and one of its forms is biliodigestive anastomosis (BDA)
which represents surgically created communication between biliary tree and gastrointestinal
tract aiming to maintain adequate bile drainage into the duodenum or jejunum.
Choledochoduodenostomy (ChDA) is one of the BDA that is characterized by fast and
simple technique of creation and small blood loss. These features make it very useful,
especially in elderly and other patients with high operative risk. ChDA is used in distal benign
biliary obstruction (papillary stenosis, chronic pancreatitis, common bile duct calculosis) and
in patients with multiple, recurrent, residual or intrahepatic calculosis. It is also useful in
patients that underwent unsuccessful endoscopic procedures or in cases when endoscopy is
not available. On the other hand, it is considered that ChDA is associated with certain percent
of complications, primarily cholangitis and „sump“ syndome that occur as a consequence of
duodeno-biliary reflux that may be present after ChDA creation.
In surgery Clinic in Nis there is a huge experience in BBO treatment. Our study
included 100 operated patients in whom ChDA was created for BBO (50 were analyzed
retrospectively and 50 prospectively). Some of the analyzed parameters were determined
preoperatively, some intraoperatively (duration of surgery, operative technique, blood loss)
and some postoperatively (during postoperative recovery and five years after surgery). After
the analysis of the data obtained the safety, efficiency and competence of ChDA were
determined, both during the postoperative recovery period and long-term, five years after
The data analysis was done using contemporary methodology and it was determined
that ChDA was fast, simple and efficient anastomosis useful in treatment of certain forms of
BBO. Serious complications occur in a small percentage and it is possible to avoid them with
adequate choice of indication and meticulous operative technique.
Complications during postoperative recovery occurred in 14,3% of our patients, with
predominance of minor surgical complications (grade I and II, transient conditions that did
not require invansive treatment).
Immediately after the ChDA creation, duodeno-biliary reflux occur in almost all of the
cases (registered in 91,7% of our patients). After 5 years the percentage of this reflux
decreases to 21,9% and is not always associated with pathophysiological consequences.
Although defined as “reflux” anastomosis, ChDA is associated with small incidence of
cholangitis both during postoperative recovery period (3,1%) and long-term postoperatively
(4,88%). Dehiscence and stenosis are rare complications of this anastomosis (3,1% and 2,4%
respectively). Serious bleeding after ChDA occurred in 1,03% of our patients (in one
retrospectively analyzed patient). Intrahospital mortality was very low considering the
complex health condition of patients that underwent ChDA (2%).
After 5 years period 70,73% of patients were without any complications, 82,92% have
declared no health problems and symptoms or had very few complaints that did not required
intensive nor invasive treatment. “Sump” syndrome was detected in one of our patients
analyzed retrospectively (2,43%); chronic gastritis as a long-term consequence of ChDA was
detected in two of our patients analyzed retrospectively (4,87%).
Scintigraphy in our study patients during early and late postoperative course confirmed
the competence of the anastomosis and did not show statistically significant difference
between the groups, proving that ChDA is not only fast but also definitive treatment of
Due to its indisputable efficiency in the treatment of certain types of biliary obstruction,
learning precise indications and technique of performing ChDA have to be included in every
general surgeon basic skills.||en
|dcterms.abstract||Стојановић, Мирослав; Ђорђевић, Небојша; Станојевић, Горан; Карамарковић, Aлександар; Влаковић, Марина; Јеремић-Савић, Љиљана М.; Процена вредности холедоходуодено анастамозе (ХДA) у хирушком лечењу бенигних опструктивних обољења жучних путева; Процена вредности холедоходуодено анастамозе (ХДA) у хирушком лечењу бенигних опструктивних обољења жучних путева;||