Utvrđivanje povezanosti hronične plak psorijaze i osnovnih kriterijuma metaboličkog sindroma
Determination of the relation between the chronic ”an plaque” psoriasis and the main criteria of the metabolic syndrome
Damevska, Katerina S.
Faculty:Универзитет у Нишу, Медицински факултет
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Psoriasis is a hereditary chronic skin disorder affecting 1–3 % of the general population worldwide. Presently, psoriasis is considered to be a Th1/Th17 involved inflammatory disease, characterized by chronically elevated pro-inflammatory cytokine levels. The metabolic syndrome (MetS) is a cluster of interrelated common clinical disorders, including insulin resistance, obesity, glucose intolerance, hypertension, and dyslipidemia. Other unexplored confounders, including genetic factors, diet, alcohol, physical activity, drugs and psychosocial factors, may contribute to several aspects of the metabolic syndrome. Previous studies have shown a possible association between psoriasis and the MetS. It has been hypothesized that this association may be explained by the state of chronic low-grade inflammation. There is little information available on the effects of drugs on the metabolic syndrome. Drugs used to treat psoriasis can adversely affect individual components of the MetS such as blood
pressure and lipid concentrations. Thus, the objective of this study is to determine the prevalence of the metabolic syndrome, comorbidity and comedication in patients with psoriasis who have never received any systemic antipsoriatic drugs. The psoriatic patients were recruited from the University Clinic of Dermatology, at the Medical Faculty in Skopje between September 2011 and April 2012. The inclusion criteria for the patients were: age > 18 years and clinical diagnosis of plaque-type psoriasis lasting for at least six consecutive months. The study included only untreated patients. Thus, patients receiving systemic antipsoriatic drugs including acitretin, cyclosporine, methotrexate, psoralen-ultraviolet A therapy and biologics, were excluded. In addition, patients with other types of psoriasis (guttate, erythrodermic and pustular psoriasis), and patients with a history of autoimmune disorders were also excluded. Data collection included demographics, weight, height, waist circumference, BMI, blood pressure, smoking and drinking habits, age of psoriasis onset, type and severity of psoriasis, and presence of psoriatic arthropathy. Each control was matched to a case according to age (±1 year) and gender. The severity of psoriasis was assessed according to the Psoriasis Area and Severity Index (PASI) and the body surface area (BSA). The MetS was diagnosed by the presence of three or more of the criteria of the National Cholesterol Education Program’s (ATP III). Odds ratios (OR) were estimated by logistic regression models using the conditional likelihood and 95 % confidence intervals (CI) were computed. The proportion of the metabolic syndrome and its individual components for the patients was compared with their matched healthy controls. Comparisons were made using the Student’s t-test for parametric continuous variables, the Mann-Whitney U test for nonparametric continuous variables, and the Chi-square test for qualitative variables. The potential predictive factors of the MetS were identified with univariate and multivariate logistic regression. The significance was set at p ≤ 0.05 for all tests. One hundred and twenty-two patients with psoriasis (52 male and 70 female, mean age 51.52 years, SD 15.56, range 19–80 years), and 122 age- and gender-matched controls (mean age 51.98, range 19–79 years) participated in the study. No statistically significant difference was noted in age between the groups (p = 0.82). Type I psoriasis occurred in 78 patients (63.9 %). The mean duration of psoriasis was 17.9 years (range 1–65 years). PASI score ranged from 2.4 to 62.0 (mean 14.75), and 56 (45.9 %) had moderate to severe psoriasis. There was no significant difference in the prevalence of the MetS between the patients with psoriasis (24.6 %) and the controls (22.9 %) (OR 1.095, 95 % CI 0.607–1.974, p = 0.764). Among the individual components of the metabolic syndrome, hypertriglyceridemia and abdo-minal obesity were associated with psoriasis. The prevalence of hypertriglyceridemia in the patients with psoriasis and the controls was 41.8 % and 28.7 %, respectively (OR 1.78, 95 % CI 1.04–3.04, p = 0.032). The prevalence of abdominal obesity in the patients with psoriasis and the controls was 56.5 % and 35.2 %, respectively (OR 2.07, 95 % CI 1.24– 3.46, p = 0.005). There were no significant differences regarding the prevalence of hypertension, low HDL cholesterol and fasting plasma glucose between cases and controls. Smoking was significantly more often noted in psoriasis patients compared with controls (OR 1.813, 95 % CI 1.091–3.013, p = 0.021). The patients with psoriasis had a higher mean BMI (26.24, SD 4.42) compared with the controls (24.73, SD 3.86 ), p = 0.005. The patients were divided in two groups, according to the presence or absence of the MetS. The psoriatic patients with the MetS had a higher mean age (p = 0.001), and higher mean BMI (p = 0.001) compared with the patients without the MetS. The presence of the MetS was not associated with the severity of psoriasis (p = 0.674). Furthermore, there were no differences regarding gender, smoking and drinking habits, clinical characteristics of psoriasis, and presence of PsA. Univariate and multivariate logistic regression analyses were conducted to identify the variables predictive of the metabolic syndrome. The analyses identified age (OR 1.049, 95 % CI 1.014–1.085, p = 0.005), BMI (OR 1.268, 95 % CI 1.124–1.430, p < 0.001), and elevated triglycerides (OR 35.59, 95 % CI 12.593–100.6, p < 0.001), as significant predictors of the MetS. The growing body of evidence suggests a possible link between psoriasis and cardiovascular risks. Three elements contribute to the unfavorable cardiovascular risk profile in patients with psoriasis: systemic inflammation, systemic therapies and unhealthy lifestyle. Over the last decade, the association between psoriasis and the MetS has been well researched. A number of small case-control studies, large population-based studies, aView More
Keywords:Psorijaza, Metabolički sindrom, Komorbidna stanja, Komedikacija, Kardiovascularni rizik, Antipsorijatični lekovi; Psoriasis, Metabolic syndrome, Comorbidity, Comedication, Cardiovascular risk factors, Antipsoriatics