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Comparative clinic, immunologic, cytogenetic and karyometric analysis of acute leukemias

dc.contributor.advisorMihailović, Dragan
dc.contributor.otherMačukanović, Lana
dc.contributor.otherPopović, Stevan
dc.creatorGovedarović, Nenad
dc.date.accessioned2016-01-05T13:22:41Z
dc.date.available2016-01-05T13:22:41Z
dc.date.available2020-07-03T16:07:28Z
dc.date.issued2011-06-15
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/3906
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=802
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:780/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=1024085741
dc.description.abstractAcute myeloid leukemia (AML) is a malignant disease with fulminant course, which results in a high percentage of patients remaining unfavourable. The aim of our researche is to define potentially new prognostic factors and to campare them with standard, well established, prognostic factors in AML. Study group included 123 newly diagnosed patients, with mean age about 65yr., with diagnosis AML Mo-M5, according to FAB classification. After diagnosis, all patients underwent karyometricanalyses (eg. measure of leukemic blast nuclei parameters), convenctional karyotype analysis, molecular analyses of FLT3 ITD mutation, as well as immunofenotype analisis by flow cytometry. According to results, it can be concluded that the main adverse actors in AML are: advanced age of patient, leucopenia or white blood cells count higher than 100000 x 10 on 9th/1 presence of FLT3 ITD mutation and higher siye of myeloblast's nuclei.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Медицински факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nd/4.0/
dc.sourceУниверзитет у Нишуsr
dc.subjectAkutna mijeloidna leukemijasr
dc.subjectCitodijagnostikasr
dc.titleKomparativna klinička, imunološka, citogenetska i kariometrijska analiza akutnih leukemijasr
dc.titleComparative clinic, immunologic, cytogenetic and karyometric analysis of acute leukemiasen
dc.typedoctoralThesisen
dc.rights.licenseBY-ND
dcterms.abstractМихаиловић, Драган; Поповић, Стеван; Мачукановић, Лана; Говедаровић, Ненад; Компаративна клиничка, имунолошка, цитогенетска и кариометријска анализа акутних леукемија; Компаративна клиничка, имунолошка, цитогенетска и кариометријска анализа акутних леукемија;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/53246/Disertacija.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/53246/Disertacija.pdf
dc.identifier.doi10.2298/ni20110615govedarovic
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_3906


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