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Ekotoksičnost nanočestica oksida metala i potencijalne metode za njihov biomonitoring u akvatičnim ekosistemima

dc.contributor.advisorMilošević, Đurađ
dc.contributor.otherZarubica, Aleksandra
dc.contributor.otherStojković-Piperac, Milica
dc.contributor.otherCvetković, Vladimir
dc.contributor.otherKolarević, Stoimir
dc.creatorSavić-Zdravković, Dimitrija
dc.date.accessioned2021-03-23T10:02:37Z
dc.date.available2021-03-23T10:02:37Z
dc.date.issued2020-10-23
dc.identifier.urihttp://eteze.ni.ac.rs/application/showtheses?thesesId=7996
dc.identifier.urihttps://fedorani.ni.ac.rs/fedora/get/o:1688/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70052&RID=24577289
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/18151
dc.descriptionThis research deals with ecotoxicity of insoluble metal oxide nanoparticles, that deposit at the bottom of aquatic ecosystems and therefore influence the hydrobiocenosis community: titanium dioxide nano-TiO2 (used as a food colour), cerium oxide nano-CeO2 (used in the automotive industry) and iron oxide nano-Fe3O4 (magnetic particles manufactured for medicinal use). Detailed characterisation of examined nanoparticles was conducted through contemporary analytical methods (for the analysis of specific surface-BET; surface chemistry-XPS; phase and crystal structure-XRD; size, aggregation and sample photographing-TEM, SEM and AFM; qualitative and quantitative element analysis-EDX; hydrodynamic diameter, polydispersity index and ζ-potential-DLS; in situ nanoparticle characterisation in the experimental sediment-EDX and SEM). Multiparametric bioassays were conducted, according to the OECD protocol, on aquatic model organisms: Chironomidae (Diptera): Chironomus tentans and Chironomus riparius. A series of standard (mortality, survival rate, developmental time and rate and emergence delay), as well as nonstandard biomarkers were analysed (oxidative stress-lipid and protein oxidation, SOD and CAT activity, expressed by total protein content; in vivo genotoxicity via DNA damage analysis; haemoglobin concentration; morphological variability change). For the first time in known literature geometric morphometric method was used for comprehensive nanoparticle toxicity analysis. Bioaccumulation of all tested nanoparticles by model organisms has been proven. The sublethal toxicity of titanium, cerium and iron oxide nanoparticles was determined, while in the case of nano-TiO2, a lethal effect was observed as well. Modified OECD protocol number 218 that implies using C. riparius as model organism, fine quartz sand substrate, detailed nanoparticle characterization, bioaccumulation analysis, analysis of standard and complementary sublethal biomarkers, enables efficient assessment of toxicity and monitoring of nanoparticles in aquatic ecosystems.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Нишу, Природно-математички факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43002/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200124/RS//
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Нишуsr
dc.subjectNanočesticesr
dc.subjectnanoparticlesen
dc.subjectaquatic midgesen
dc.subjectChironomusen
dc.subjectbioassaysen
dc.subjectbiomarkersen
dc.subjectOECD protocolen
dc.subjectgeometric morphometricsen
dc.subjecttitanium dioxide TiO2en
dc.subjectcerium oxide CeO2en
dc.subjectiron oxide Fe3O4en
dc.subjecthironomidesr
dc.subjectChironomussr
dc.subjectbiološki testovisr
dc.subjectbiomarkerisr
dc.subjectOECD protokolsr
dc.subjectgeometrijska morfometrijasr
dc.subjecttitanijum dioksid TiO2sr
dc.subjectcerijum oksid CeO2sr
dc.subjectgvožđe oksid Fe3O4sr
dc.titleEkotoksičnost nanočestica oksida metala i potencijalne metode za njihov biomonitoring u akvatičnim ekosistemimasr
dc.typePhD thesis
dc.rights.licenseBY-NC-ND
dcterms.abstractМилошевић, Ђурађ; Зарубица, Aлександра; Коларевић, Стоимир; Цветковић, Владимир; Стојковић-Пиперац, Милица; Савић-Здравковић, Димитрија; Екотоксичност наночестица оксида метала и потенцијалне методе за њихов биомониторинг у акватичним екосистемима; Екотоксичност наночестица оксида метала и потенцијалне методе за њихов биомониторинг у акватичним екосистемима;
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/70371/Savic_Zdravkovic_Dimitrija_N.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/70370/Disertacija.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_18151


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