Show simple item record

Natural styryl-lactones, their derivatives and analogues as potential antitumour agents: Design, synthesis and a SAR study

dc.contributor.advisorPopsavin, Velimir
dc.contributor.otherPopsavin, Mirjana
dc.contributor.otherPopsavin, Velimir
dc.contributor.otherSakač, Marija
dc.contributor.otherŠolaja, Bogdan
dc.creatorKovačević, Ivana
dc.date.accessioned2015-12-29T11:16:39Z
dc.date.available2015-12-29T11:16:39Z
dc.date.issued2015-04-29
dc.identifier.urihttp://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija143039372942779.pdf?controlNumber=(BISIS)94214&fileName=143039372942779.pdf&id=3640&source=NaRDuS&language=srsr
dc.identifier.urihttp://www.cris.uns.ac.rs/record.jsf?recordId=94214&source=NaRDuS&language=srsr
dc.identifier.urihttp://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije142769656969348.pdf?controlNumber=(BISIS)94214&fileName=142769656969348.pdf&id=3420&source=NaRDuS&language=srsr
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/1685
dc.descriptionU radu je ostvarena sinteza četiri prirodna proizvoda, goniobutenolida A i B, krasalaktona D i 3-deoksi-kardiobutanolida i 32 derivata i analoga polazeći iz D-glukoze. Sinteza prirodnog stiril-laktona, kardiobutanolida  i njegova 4 derivata je izvedena polazeći iz  D-ksiloze.  Ispitan je uticaj sintetizovanih jedinjenja  na inhibiciju rasta 10 tumorskih i jedne zdrave ćelijske linije. Uspostavljene su i  korelacije izmedju strukture i antiproliferativne aktivnosti (SAR) i ispitan je mehanzam antitumorskog dejstva.sr
dc.descriptionSynthesis of four natural products: goniobutenolide A and B, crassalactone D, 3-deoxy-cardiobutanolide and their 32 analogues and derivatives is accomplished starting from  D-glucose. Synthesis of natural styryl lactone cardiobutanolide and its four derivatives is  achieved  starting  from  D-xylose.  Synthesized natural lactones, their analogues and derivatives were evaluated for their antiproliferative activity against ten malignant cell lines  as well as against a single normal cell line. Influence of functional groups on antitumour activity was established by correlating structures of synthesized compounds  with  their  biological  activity (SAR).  Also, mechanism of antitumour action was investigated.en
dc.languagesr (latin script)
dc.publisherУниверзитет у Новом Саду, Природно-математички факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172006/RS//
dc.rightsAttribution-NonCommercial-NoDerivs
dc.sourceУниверзитет у Новом Садуsr
dc.subjectCitotoksični stiril-laktonisr
dc.subjectCytotoxic styryl lactonesen
dc.subjectgoniobutenolidi A i Bsr
dc.subjectkrasalakton Dsr
dc.subjectkardiobutanolidsr
dc.subject3-deoksi-kardiobutanolidsr
dc.subjectsinteza analoga i derivatasr
dc.subjectD-glukozasr
dc.subjectD-ksilozasr
dc.subjectantiproliferativna aktivnostsr
dc.subjectgoniobutenolide A and Ben
dc.subjectcrassalactone Den
dc.subjectcardiobutanolideen
dc.subject3-deoxy-cardiobutanolideen
dc.subjectsynthesis od analogues and derivativesen
dc.subjectD-glucoseen
dc.subjectD-xyloseen
dc.subjectantiproliferative activityen
dc.titlePrirodni stiril-laktoni, njihovi derivati i analozi kao potencijalni antitumorski agensi: Dizajn, sinteza i SAR ispitivanjasr
dc.titleNatural styryl-lactones, their derivatives and analogues as potential antitumour agents: Design, synthesis and a SAR studyen
dc.typeDoktorska disertacijasr
dcterms.abstractПопсавин Велимир; Шолаја Богдан; Попсавин Мирјана; Попсавин Велимир; Сакач Марија; Ковачевић Ивана; Природни стирил-лактони, њихови деривати и аналози као потенцијални антитуморски агенси: Дизајн, синтеза и СAР испитивања; Природни стирил-лактони, њихови деривати и аналози као потенцијални антитуморски агенси: Дизајн, синтеза и СAР испитивања;


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record