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Effect of repurposing non-cancer drugs on experimental fibrosarcoma in hamsters

dc.contributor.advisorLalošević, Dušan
dc.contributor.advisorKolarović, Jovanka
dc.contributor.otherGudurić, Branimir
dc.contributor.otherKolarović, Jovanka
dc.contributor.otherLalošević, Dušan
dc.contributor.otherMihailović, Jasna
dc.contributor.otherNikolić, Božana
dc.creatorPopović, Dušica
dc.date.accessioned2019-07-18T12:48:02Z
dc.date.available2019-07-18T12:48:02Z
dc.date.available2020-07-03T13:28:44Z
dc.date.issued2019-06-04
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/11236
dc.identifier.urihttps://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija155168967070744.pdf?controlNumber=(BISIS)110281&fileName=155168967070744.pdf&id=12670&source=NaRDuS&language=srsr
dc.identifier.urihttps://www.cris.uns.ac.rs/record.jsf?recordId=110281&source=NaRDuS&language=srsr
dc.identifier.urihttps://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije155168967965029.pdf?controlNumber=(BISIS)110281&fileName=155168967965029.pdf&id=12671&source=NaRDuS&language=srsr
dc.description.abstractMnogi lekovi registrovani za razne druge indikacije mogu da deluju selektivno na tumorske receptore, signalne puteve, metaboličke procese, bioenergetske faktore, enzime, proteine, gene koji regulišu proliferaciju, apoptozu i neoangiogenezu tumora ne pogađajući ove procese kod zdravih ćelija. Uvođenje novih lekova je izrazito dug, složen i skup proces istraživanja. Korišćenjem principa otkrivanja antikancerskog efekta kod već registrovanih lekova za druge indikacije, direktno se utiče na skraćivanje vremena i troškova istraživanja. Eksperimentalno je ispitana efikasnost antitumorskog delovanja mebendazola, metformina, itrakonazola, diklofenaka, nitroglicerina i deoksiholne kiseline na fibrosarkom hrčka izazvan BHK21/C13 tumorskom ćelijskom linijom praćenjem veličine i histologije lečenih tumora. Eksperimentalno je ispitana mogućnost primene deoksiholne kiseline, nitroglicerina, kofeina i itrakonazola kao adjuvansa u kombinaciji sa pojedinim ispitivanim lekovima (metformin, itrakonazol, diklofenak) za lečenje fibrosarkoma hrčka. Kako je ispitivanje vršeno na mladuncima imladim hrčkovima i kako su sarkomi najčešći u dečijem uzrastu, definisanje potencijalne antikancerske uloge ispitivanih lekova se odnosi prvenstveno na njihovu primenu u pedijatriji. Pokazano je da metformin, kombinacije metformina sa kofeinom, metformina sa itrakonazolom i metformina sa nitroglicerinom deluju u pogledu svih ispitivanih parametara tumora antitumorski na fibrosarkom hrčka. Kofein, itrakonazol i nitroglicerin pojačavaju antitumorsko dejstvo metformina na fibrosarkom hrčka. Tokom svih eksperimenata realizovanih u okviru ove disertacije, pokazalo se da nije bilo delotvornog tretmana, koji ne sadrži metformin.sr
dc.description.abstractMany drugs registered for various other indications can act selectively to tumor receptors, signaling pathways, metabolic processes, bioenergetic factors, enzymes, proteins, genes that regulate proliferation, apoptosis, and neoangiogenesis of the tumor without affecting these processes in the healthy cells. The introduction of new drugs is a very long, complex and expensive process of research. Using the principle of detecting the anticancer effect in already registered drugs for other indications, directly affects the reduction of time and cost of research. The efficacy of mebendazole, metformin, itraconazole, diclofenac, nitroglycerin and deoxycholic acid antitumor activity on hamster fibrosarcinoma induced experimentally by the BHK21/C13 tumor cell line was tested by monitoring the size and histology of the treated tumors. The possibility of using deoxycholic acid, nitroglycerin, caffeine and itraconazole as an adjuvant in combination with investigated drugs (metformin, itraconazole, diclofenac) for the treatment of hamster fibrosarcoma has been experimentally tested. As the examination was carried out on young cubs and young hamsters and that sarcomas are the most common in childhood, defining the potential anti-cancer role of the investigated drugs relates primarily to their application in pediatrics. Metformin, combinations of metformin with caffeine, metformin with itraconazole and metformin with nitroglycerin have shown antitumor action on the hamster fibrosarcoma in terms of all tested tumor parameters. Caffeine, itraconazole and nitroglycerin increase the antitumor effect of metformin on the hamster fibrosarcoma. During all the experiments carried out within this dissertation, there has been no effective treatment, which does not contain metformin.en
dc.languagesr (latin script)
dc.publisherУниверзитет у Новом Саду, Медицински факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Новом Садуsr
dc.subjecteksperimentalni sarkom + terapija lekovimasr
dc.subjectSarcomaen
dc.subjectExperimental + drug therapyen
dc.subjectmetforminsr
dc.subjectmebendazolsr
dc.subjectitrakonazolsr
dc.subjectdiklofenaksr
dc.subjectnitroglicerinsr
dc.subjectdeoksiholna kiselinasr
dc.subjectkofeinsr
dc.subjecteksperiment na životinjamasr
dc.subjectsirijski zlatni hrčaksr
dc.subjectMetforminen
dc.subjectMebendazoleen
dc.subjectItraconazoleen
dc.subjectDiclofenacen
dc.subjectNitroglycerinen
dc.subjectDeoxycholic Aciden
dc.subjectCaffeineen
dc.subjectAnimal Experimentationen
dc.subjectMesocricetusen
dc.titleDelovanje lekova registrovanih za neonkološke indikacije na eksperimentalni fibrosarkom hrčkasr
dc.title.alternativeEffect of repurposing non-cancer drugs on experimental fibrosarcoma in hamstersen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/35549/Disertacija.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/35550/IzvestajKomisije.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/35549/Disertacija.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/35550/IzvestajKomisije.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_11236


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