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Influnce of niacin on lipide profile and metabolic adaptation in dairy cows during early lacttion

dc.contributor.advisorCincović, Marko R.
dc.contributor.advisorStojanović, Dragica
dc.contributor.otherJezdimirović, Milanka
dc.contributor.otherToholj, Bojan
dc.contributor.otherBelić, Branislava
dc.creatorHristovska, Talija
dc.date.accessioned2019-05-16T11:25:43Z
dc.date.available2019-05-16T11:25:43Z
dc.date.available2020-07-03T13:34:56Z
dc.date.issued2017-12-22
dc.identifier.urihttps://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija150530211370718.pdf?controlNumber=(BISIS)105028&fileName=150530211370718.pdf&id=10491&source=NaRDuS&language=srsr
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/11071
dc.identifier.urihttps://www.cris.uns.ac.rs/record.jsf?recordId=105028&source=NaRDuS&language=srsr
dc.identifier.urihttps://www.cris.uns.ac.rs/DownloadFileServlet/IzvestajKomisije150530212956074.pdf?controlNumber=(BISIS)105028&fileName=150530212956074.pdf&id=10492&source=NaRDuS&language=srsr
dc.description.abstractCilj ove disertacije je da se ispita uticaj aplikacije niacina na metabolizam lipida u peripartalnom periodu, da se utvrdi dali aplikacija niacina utiče na insulinsku rezistenciju, vezu između metaboličkih parametara i lipolize i ketogeneze i uticaj aplikacije niacina na koncetracije NAD i NADP. NAD i NADP predstavljaju adekvatne pokazatelje statusa niacina kod krava u ranoj laktaciji, a njihova vrednost je značajno viša kod krava koje su primale ovaj vitamin. NED i NADP pokazuju pozitivnu korelaciju. Pored ovoga izvedene vrednosti kao što je NAD:NADP indeks i površina ispod krive koju prave ovi vitameri posle teljnja zavise od aplikacije niacina. Aplikacija niacina dovodi do smanjenja koncentracije NEFA, BHB i MDA, a do povećanja koncentracije triglicerida i holesterola u krvi krava. Aplikacija niacina dovodi do porasta koncentracije insulina i glukoze kod krava posle teljenja. Uticaj niacina na insulinsku rezistenciju se mora dvojako posmatrati. Krave koje primaju niacin imaju nižu vrednost indeksa glukoza:insulin, što znači da se po jedinici insulina neutrališe manje glukoze. Ovakvo stanje nastaje jer sa porastom koncentracije insulina opada njegova efikasnost i životinje ulaze u insulinsku rezustenciju. Međutim, RQUICKIBHB indeks insulinske rezistencije je pokazao da su krave koje su primale niacin mnogo osetljivije na insulin, što se može pripisati povećanoj insulinskoj senzitivnosti masnog tkiva. Kod krava koje su primale niacin nađena je niža koncentracija bilirubina i aktivnost AST, ALP i GGT. Nađena je viša koncentracija albumina i viša koncentracija uree i niža koncentracija fosfora. Rezultati pokazuju da aplikacija niacina pozitivno utiče na status hepatocita, a može uticati i na metabolizam proteina u organizmu zbog promena u vrednosti uree. Promena metaboličkih parametara posle teljenja išla je u istom pravcu u oglednoj i kontrolnog grupu, samo se menjao intenzitet promena u funkciji aplikacije niacina. Parcijalna korelacija pokazuje da vitameri niacina mogu objasniti određeni deo korelacije koji postoji između lipolize, ketogeneze i metaboličkim parametrima. Stopa promene veze između 142   metaboličkih parametara sa NEFA i BHB zavisi od stope promene statusa niacina u organizmu krava u ranoj laktaciji. Naknadnim istraživanjima treba odrediti kauzalnu prirodu ovih veza. Krave koje su primale niacina pokazivale su tendenciju povećane proizvodnje mleka do 30. dana laktacije. Ovakav uticaj niacina se izgubio prilikom merenja u 60. danu laktacije. Krave sa boljim statusom niacina (viša vrednost NAD i NADP) pokazuju manji stepen zamašćenja i bolju vitalnost hepatocita, a nađen je i veći dijametar adipocita u potkožnom  masnom  tkivu, što se može pripisati antilipoliznom efektu niacina.sr
dc.description.abstractAB  The aim of this dissertation is to examine the effect of niacin on lipid metabolism in perpaturient period, to determine does application of niacin have effects on insulin resistance, relationship between metabolic parameters and lipolysis and ketogenesis and effects of application of niacin on NAD and NADP concentration in plasma. NAD and NADP present the adequate indicator of the status of niacin in cows in early lactation, and concentration of NAD and NADP is significant increase in cows that were treated with niacin. NAD and NADP demonstrate positive correlation. Despite this, the derived values like NAD:NADP ratio and area under the curve depends of the application of niacin. Application of niacin leads to decreased NEFA, BHB and MDA plasma concentration, and increased triglyceride and cholesterol concentration in plasma in cows. Application of niacin leads to increased concentration of insulin and glucose in plasma after partum. The effect of niacin on insulin resistance may have two sides. Cows that received niacin had lower value of  glucose:insulin ratio, that means that one unit of insulin metabolized less glucose. This state became because with increased insulin concentration decreased its efficiency and animals obtained insulin resistance. On the other hand index RQUICKIBHB for insulin resistance showed that cows that received niacin were much more sensitive to insulin, and that may be as a result of increased insulin sensitivity in adipose tissue.  Cows that have received niacin bilirubin concentration and activity of AST, ALP and GGT were decrease. Albumin concentration was increased, urea and phosphor concentration was decreased in group that had received niacin. Results indicate that application of niacin have positive impact on status hepatocytes, and may have influence on protein metabolism in organism because of alteration on value in urea. In control and niacin group alteration on metabolic parameters after partum went on the same direction, but intensity of changing was in function of application of niacin. Partial correlation indicates that niacin vitamers may explain certain part of correlation that exists between lipolysis, ketogenesis, and metabolic parameters.  Rate changes of the relationship between metabolic parameters with NEFA  and BHB depends of the rate changes of the niacin status in cows in early lactation. Subsequent research should determinate the causal nature of this relationship. Cows that have received niacin were demonstrating tendency of increased milk production until 30.day lactation. This impact of niacin was lost in 60.day of lactation. Cows with better status niacin (greater value of NAD and NADP) manifest smaller grade of hepatic lipidosis and better vitality of hepatocytes, and was found bigger 145   diameter on subcutaneous adipocytes, which can be as a result of antilipolitic effects of niacin.en
dc.languagesr (latin script)
dc.publisherУниверзитет у Новом Саду, Пољопривредни факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceУниверзитет у Новом Садуsr
dc.subjectSKW Kravesr
dc.subjectniacinsr
dc.subjectmetabolički statussr
dc.subjectinsulinska rezistencijasr
dc.titleUticaj niacina na lipidni profil i metaboličku adaptaciju krava u ranoj laktacijisr
dc.title.alternativeInflunce of niacin on lipide profile and metabolic adaptation in dairy cows during early lacttionen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/36629/Disertacija.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/36630/IzvestajKomisije.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/36629/Disertacija.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/36630/IzvestajKomisije.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_11071


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