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Evaluation of morphological parameters of musculoskeletal system tumors before and after neoadjuvant chemotherapy using magnetic resonance technique

dc.contributor.advisorMaksimović, Ružica
dc.contributor.otherMilošević, Zorica
dc.contributor.otherSopta, Jelena
dc.contributor.otherMojović, Miloš
dc.creatorĆirković, Predrag R.
dc.date.accessioned2019-02-08T15:49:36Z
dc.date.available2019-02-08T15:49:36Z
dc.date.issued2018-09-28
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=6592
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:19385/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50781711
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/10741
dc.description.abstractMuskuloskeletni tumori su heterogena grupa oboljenja koja predstavljaju značajan dijagnostički i klinički izazov, kako u pogledu lečenja, tako i medicinskih istraživanja. Uvođenje hemioterapije je poboljšalo prognozu, doprinelo povećanju procenta izlečenja, ali i pored svega neuspeh terapije je i dalje prisutan. Zbog toga rani prediktor tumorskog odgovora na primenjenu hemioterapiju bi bio veoma koristan, omogućavajući onkologu da na vreme promeni i primeni drugu terapiju u slučaju neuspeha prethodne. Kod pacijenata kod kojih se primenjuje neoadjuvantna hemioterapija, najpouzdaniji prognostički faktor je histopatološki procenjen procenat nekroze u vreme hirurške intervencije. Medjutim, ovaj parametar nije moguće znati pre i u toku hemioterapije, pa postoji potreba za identifikovanjem prognostičkih faktora koji će biti poznati pre i za vreme hemioterapije. Jedan od tih mogućih prognostičkih faktora je protonska spektroskopija (MRS), koja se zasniva na mogućnosti detekcije markera maligniteta u zoni od interesa, a s obzirom na stanovište da tumorski metabolički parametri mogu pružiti vrednu prognostičku informaciju. Cilj rada je evaluacija pouzdanosti volumetrije i MR spektroskopije u proceni terapijskog odgovora muskuloskeletnih tumora, zasnovana na korelaciji nalaza volumetrije i MR spektroskopije sa patohistološkim nalazima. Materijal i metode Istraživanje je sprovedeno u Institutu za onkologiju i radiologiju Srbije, u periodu od januara 2010. godine do decembra 2017. godine. U prospektivnu studiju je uključeno 42 pacijenta sa novootkrivenim malignim tumorima muskuloskeletnog sistema kod kojih nije započeta hemioterapija, starosti od 5 godina do 57 godina, u trenutku inicijalne hospitalizacije radi lečenja primarnog muskuloskeletnog tumora. Svim pacijentima uključenim u studiju prethodno je izvršena biopsija tumorske promene i utvrđena patohistološka dijagnoza...sr
dc.description.abstractMusculoskeletal tumours are represented by heterogeneous group of diseases with significant diagnostic and clinical challenge, both in terms of treatment as well as medical research. Although introduction of chemotherapy improved overall prognosis and survival, the therapy failure is still present. Therefore, the early predictor of the tumor response to the applied chemotherapy would be very useful, allowing the oncologist to alter and apply another therapy in the event of a failure of the previous one. In patients with applied neoadjuvant chemotherapy, the most reliable prognostic factor is the histopathologically estimated percentage of necrosis at the time of surgery. However, this parameter can not be known before and during chemotherapy, thus there is a need to identify new prognostic factors for this time point. One of these possible prognostic factors is proton spectroscopy (MRS), which is based on the ability to detect malignancy markers in the area of interest through the tumor metabolic parameters. The aim of the thesis is to evaluate the reliability of volumetry and magnetic resonance (MRI) spectroscopy in assessing the therapeutic response of musculoskeletal tumors, based on the correlation of volumetric and MRI spectroscopic data with pathohistological findings. Material and Methods The research was conducted at the Institute of Oncology and Radiology of Serbia, in the period between January 2010 and December 2017. The study was designed as prospective study which involved 42 patients at the time of initial hospitalization for the treatment of newly discovered primary musculoskeletal tumors. The age of the enrolled patients ranged from 5 to 57 years...en
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dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsAutorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)
dc.sourceУниверзитет у Београдуsr
dc.subjectMagnetna rezonancija, protonska spektroskopija, holin, volumetrija, hemioterapija, muskuloskeletni, tumor, procenasr
dc.subjectmagnetic resonance, proton spectroscopy, choline, volumetry, chemotherapy, musculoskeletal, tumor, assessmenten
dc.titleEvaluacija morfoloških parametara tumora muskuloskeletnog sistema pre i nakon neoadjuvantne hemioterapije primenom tehnika magnetne rezonancesr
dc.title.alternativeEvaluation of morphological parameters of musculoskeletal system tumors before and after neoadjuvant chemotherapy using magnetic resonance techniqueen
dc.typePhD thesis


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