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Relationship of magnesium intake from food and water with blood pressure, hemodynamic parameters and arterial function in patients with essential arterial hypertension

dc.contributor.advisorBelojević, Goran
dc.contributor.otherPlećaš, Draga
dc.contributor.otherDekleva-Manojlović, Milica
dc.contributor.otherNikolić, Maja
dc.creatorBanjanin, Nikolina Đ.
dc.date.accessioned2019-02-08T15:49:35Z
dc.date.available2019-02-08T15:49:35Z
dc.date.issued2018-09-27
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=6587
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:19378/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50791439
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/10739
dc.description.abstractRezultati dosadašnjih istraživanja o povezanosti magnezijuma unetog hranom i vodom i serumskog magnezijuma sa krvnim pritiskom, hemodinamskim parametrima i funkcijom arterija kao i efektima suplementacije magnezijumom na navedene parametre kod obolelih od esencijalne arterijske hipertenzije su heterogeni. Ovo je bio razlog za preduzimanje našeg istraživanja. Ciljevi istraživanja su bili: 1) Proceniti unos magnezijuma hranom i vodom kod ispitanika sa hipertenzijom; 2) Ispitati povezanost magnezijuma unetog hranom i vodom i serumskog magnezijuma sa vrednostima krvnog pritiska, hemodinamskim parametrima i funkcijom arterija kod ispitanika sa hipertenzijom i 3) Ispitati promene vrednosti krvnog pritiska, hemodinamskih parametara i funkcije arterija posle uzimanja oralnog preparata magnezijuma kod ispitanika sa hipertenzijom. Metod. Istraživanje se sastojalo iz dve faze, i to iz studije preseka (prva faza) i iz interventne studije (druga faza). Studija je sprovedena u Multidisciplinarnom centru za polikliničku dijagnostiku, ispitivanje i lečenje poremećaja krvnog pritiska Kliničkog centra Srbije u Beogradu, u periodu od septembra 2014. godine do juna 2016. godine. Interventna studija je registrovana u Iranskom registru kliničkih studija (www.irct.ir; Registracioni broj: IRCT2017081535716N1). Studija je sprovedena u skladu sa Helsinškom deklaracijom, i odobrili su je Etički odbor Kliničkog centra Srbije u Beogradu i Etički komitet Medicinskog fakulteta Univerziteta u Beogradu. U prvu fazu istraživanja uključeno je 434 ispitanika (154 muških i 280 ženskih), starosti od 18 do 65 godina, sa prosečnom dobi 47,7±12,9 godina, sa dijagnozom esencijalne arterijske hipertenzije. U studiju nisu uključeni ispitanici sa oboljenjem bubrega, bolestima gastrointestinalnog trakta, dijabetesom melitusom, oboljenjima nadbubrežne, tireoidne i paratireoidne žlezde, anginom pektoris, infarktom miokarda, kongestivnom srčanom insuficijencijom, koronarnom revaskularizacijom, tranzitornim ishemijskim atakom, koarktacijom aorte, alergijom na hranu i lekove, trudnice i dojilje, i sa oralnom suplementacijom magnezijumom u prethodnih mesec dana...sr
dc.description.abstractThe results of previous studies on the association of magnesium intake from food and water and serum magnesium with blood pressure, hemodynamic parameters and arterial function as well as the effects of magnesium supplementation on the mentioned parameters in patients with essential arterial hypertension are heterogeneous. This was the reason for undertaking our study. The aims of the study were: 1) To evaluate the intake of magnesium from food and water in subjects with hypertension; 2) To examine the association of magnesium from food and water and serum magnesium with blood pressure, hemodynamic parameters and arterial function in subjects with hypertension and 3) To examine changes in blood pressure, hemodynamic parameters and arterial function after oral magnesium supplementation in subjects with hypertension. Method. The study comprised two phases, a cross-sectional study (first phase) and an intervention study (second phase). The study was performed in Multidisciplinary Center for Polyclinic Diagnostics, Assessment and Treatment of Blood Pressure Disorders, Clinical Center of Serbia, Belgrade. The intervention study was registered by The Iranian Registry of Clinical Trials (www.irct.ir; Registration number: IRCT2017081535716N1). The study was conducted in accordance with the declaration of Helsinki, and the study protocol was approved by the Ethics Committee of the Clinical Center of Serbia, Belgrade and by the Ethics Committee of the Faculty of Medicine, University of Belgrade, Serbia. The first phase of the study included 434 subjects (154 male and 280 female), aged from 18 to 65 years, with an average age of 47.7 ± 12.9 years, with the diagnosis of essential hypertension. The study did not include subjects with kidney disease, gastrointestinal tract disorders, diabetes mellitus, adrenal, thyroid and parathyroid gland diseases, angina pectoris, myocardial infarction, congestive heart failure, coronary revascularization, transient ischemic attack, aortic coarctation, food and drug allergy, pregnancy and lactation and oral magnesium supplementation during the previous one month...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Медицински факултетsr
dc.rightsAutorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
dc.sourceУниверзитет у Београдуsr
dc.subjectmagnezijum; dijetetski suplementi; hipertenzija; sistemska vaskularna rezistencija, minutni volumen srcasr
dc.subjectmagnesium; dietary supplements; hypertension; systemic vascular resistance, cardiac outputen
dc.titlePovezanost unosa magnezijuma hranom i vodom sa krvnim pritiskom, hemodinamskim parametrima i funkcijom arterija kod obolelih od esencijalne arterijske hipertenzijesr
dc.title.alternativeRelationship of magnesium intake from food and water with blood pressure, hemodynamic parameters and arterial function in patients with essential arterial hypertensionen
dc.typePhD thesis


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