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Heart rate variation and DNA damage in haemocytes of the mediterranean mussel Mytilus galloprovincialis L. as biomarkers of marine pollution

dc.contributor.advisorGačić, Zoran
dc.contributor.otherKolarević, Stoimir
dc.contributor.otherVuković-Gačić, Branka
dc.contributor.otherĐurović, Mirko
dc.contributor.otherAnđus, Pavle
dc.creatorMartinović, Rajko B.
dc.date.accessioned2018-11-26T14:49:18Z
dc.date.available2018-11-26T14:49:18Z
dc.date.available2020-07-03T08:04:58Z
dc.date.issued2018-09-24
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=6184
dc.identifier.urihttps://nardus.mpn.gov.rs/handle/123456789/10146
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:18766/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50643215
dc.description.abstractIntegrisani pristup biomonitoringa koji uključuje bateriju biotestova, omogućava pouzdaniju detekciju različith vrsta organskog i neorganskog zagađenja u cilju procjene stanja u morskom ekosistemu. U ovom radu je praćen uticaj hemijskih stresora na srčani ritam mediteranske dagnje pri kratkotrajnim tretmanima ex situ. Pošto biomarkeri na ćelijskom i molekularnom nivou imaju veću specifičnost, u cilju unaprijeđenja pouzdanosti i praktične primjenljivosti srčanog ritma kao fiziološkog biomarkera, uradjeni su i produženi tretmani dagnji, takođe ex situ, u kojima su uporedno analizirani srčani ritam i oštećenja DNK u hemocitama mediteranske dagnje. Pri kratkotrajnim tretmanima, ispitivan je uticaj promjene u salinitetu morske vode na srčani ritam dagnji koji je praćen fotopletizmografski, fiber-optic metodom. Takođe, ispitivan je odgovor srčanog ritma dagnje pri izlaganju kadmijum hloridu, dizel gorivu, naftnom disperzantu Superdispersant-25 i dispergovanom dizelu, pri čemu je potvrđena sposobnost dagnji da detektuju stres u ranoj fazi. Prilikom produženih tretmana dagnji, uporedno sa praćenjem srčanog ritma, procijenjen je genotoksični potencijal kadmijum hlorida kao model mutagena, dizel goriva, Superdispersant-25, benzo(a)pirena i tributil kalaj hlorida kao zagađivača čija kontrola je od velikog značaja. Uz komet test koji je služio za procjenu oštećenja DNK, genotoksični potencijal tributil kalaj hlorida, analiziran je mikronukleus testom i prokariotskim SOS/umuC testu in vitro. Dobijeni rezultati su pokazali da je dispergovani dizel mnogo opasniji po školjke usljed veće dostupnosti njegovih sastojaka. Rezultati praćenja srčanog ritma pri tretmanima tributil kalaj hloridom mogu se povezati sa podacima dobijenim u genotoksikološkim testovima što ukazuje da bi se srčani ritam dagnji mogao koristiti kao pouzdan biomarker u detekciji zagađenja porijeklom od organokalajnih jedinjenja. Na osnovu rezultata dobijenih pri kratkotrajnim i produženim tretmanima organskim i neorganskim zagađivačima, srčani ritam mediteranske dagnje se može preporučiti za korišćenje kao sastavni dio integrisanog pristupa u biomonitoringu zagađenja mora.sr
dc.description.abstractreliable detection of different types of organic and inorganic pollutants which would improve the evaluation of the state of the marine ecosystem. In this study, the influence of short-term treatments by chemical stressors on the heart rate of the Mediterranean mussel was monitored ex situ. Since cellular and molecular biomarkers are characterized by higher specificity, extended treatments for comparative analyses of the heart rate and DNA damage in haemocytes were performed to improve reliability and applicability of the Mediterranean mussel’s heart rate as a physiological biomarker. Fiber-optic method, based on photoplethysmography, was applied for studying the influence of variations in seawater salinity on the heart rate of mussels. The influence of cadmium chloride, diesel oil, oil dispersant Superdispersant-25 and dispersed diesel oil was studied as well, whereby the ability of mussel’s heart rate to detect stress at an early stage was confirmed. Comparative analyses of mussel’s heart rate and genotoxic potential of cadmium chloride as a model mutagen, diesel oil, Superdispersant-25, benzo(a)pyrene and tributyltin as pollutants of importance to control, in extended treatments were assessed. Comet assay was used for the assessment of DNA damage. Moreover, genotoxic potential of tributyltin was assessed in vitro by micronucleus test and prokaryotic SOS/umuC assay. The results indicated that dispersed diesel oil was more harmful for mussels due to enhanced availability of its compounds. Heart rate results obtained in tributyltin chloride treatments can be linked to the data obtained in genotoxicological assays indicating that musels‘s heart rate could be used as a reliable biomarker for detection of organotin pollution. The results obtained in short-term and extended treatments by organic and inorganic pollutants indicated that heart rate of the Mediterranean mussel can be included as a part of the integrated approach of marine pollution biomonitoring.en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Биолошки факултетsr
dc.rightsopenAccessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceУниверзитет у Београдуsr
dc.subjectsrčani ritamsr
dc.subjectheart rateen
dc.subjectoštećenje DNKsr
dc.subjectmediteranska dagnjasr
dc.subjectMytilus galloprovincialissr
dc.subjectbiomarkerisr
dc.subjectzagađenje morasr
dc.subjectDNA damageen
dc.subjectMediterranean musselen
dc.subjectMytilus galloprovincialisen
dc.subjectbiomarkersen
dc.subjectmarine pollutionen
dc.titlePromjenljivost srčanog ritma i oštećenje DNK u hemocitama kod mediteranske dagnje Mytilus galloprovincialis L. kao biomarkeri zagađenja morasr
dc.title.alternativeHeart rate variation and DNA damage in haemocytes of the mediterranean mussel Mytilus galloprovincialis L. as biomarkers of marine pollutionen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-SA
dcterms.abstractГачић, Зоран; Aнђус, Павле; Ђуровић, Мирко; Вуковић-Гачић, Бранка; Коларевић, Стоимир; Мартиновић, Рајко Б.;
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/943/IzvestajKomisije18352.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/942/Disertacija.pdf
dc.identifier.fulltexthttps://nardus.mpn.gov.rs/bitstream/id/943/IzvestajKomisije18352.pdf
dc.identifier.fulltexthttp://nardus.mpn.gov.rs/bitstream/id/942/Disertacija.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_nardus_10146


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