Intersticijalne ćelije kahala u gastrointestinalnom traktu pacova sa dijabetesom melitusom izazvanim streptozotocin-nikotinamidom
Докторанд
Veličkov, Aleksandra I.Ментор
Radenković, GoranЧланови комисије
Avramović, VericaSokolović, Dušan
Mihailović, Dragan
Lalošević, Dušan
Метаподаци
Приказ свих података о дисертацијиСажетак
Interstitial cells of Cajal (ICC) are non-neural cells of mesenchymal
origin inserted between nerve elements and smooth muscle cells in the
gastrointestinal tract (GIT). ICC are necessary for normal function of
gastrointestinal (GI) tract and according to their morphology, function
and localization, ICC are classified in several subtypes. Certain ICC
subtypes serve as source of electrical slow waves which are
electrophysiological foundation of peristalsis, while other ICC
subtypes are mediators and modulators of enteric motor
neurotransmission, mechanoreceptors and are responsible for proper
function of GIT sphincters. Mechanism of diabetic gastroenteropathy
(DG) is unclear. ICC disorders caused by metabolic changes in
diabetes (DM) could explain symptoms of DG (gastroparesis, slow
intestinal transit, constipation, fecal incontinence). The aim of research
is to determine ICC distribution and morphology in GIТ of rats in
control group and rats with streptozotocin-nicotinam...ide induced DM
using immunohistochemical and morphometric methods. The results of
doctoral dissertation showed that all ICC subtypes are present in the
GIT of the rat, with regional distribution and density differences. In the
DM group, there was a significant diffuse loss of all subtypes of ICC
in GIT, while the density of nerve structures remained unchanged.