Prediktivna vrednost metaboličkog sindroma u proceni toka i ishoda trudnoće
The predictive value of metabolic syndrome in evaluation of pregnancy course and outcome
Докторанд
Trišović, Marija M.Ментор
Pervulov, MiroslavaЧланови комисије
Plećaš, DarkoLalić, Katarina
Bila, Sreten
Метаподаци
Приказ свих података о дисертацијиСажетак
Uvod: Termin metabolički sindrom (MS), sindrom insulinske rezistencije i sindrom
X, koristi se za precizno definisanje udruženih abnormalnosti koje su povezane sa
povećanim rizikom za razvoj dijabetes melitusa tipa 2 i aterosklerotskih
kardiovaskularnih bolesti. Uniformna definicija MS ne postoji.
Ciljevi rada: Utvrđivanje učestalosti MS u ispitivanom uzorku; ispitivanje
povezanosti između osnovnih socio - demografskih karakteristika trudnica i MS;
prisustva specifičnih navika trudnica i MS; ispitivanje pojedinih komponenti MS u
trudnoći; ispitivanje prognostičkog značaja metaboličkog sindroma u proceni toka i
ishoda trudnoće.
Materijal i metode: Prospektivna, kohornta studija je obuhvatila 135 trudnica,
hospitalizovanih u periodu 2013. i 2014. godine. Korišćena je medicinska
dokumentacija Klinike za ginekologiju i akušerstvo, Kliničkog centra Srbije, kao i
posebno, formiran strukturalni upitnik. Za analizu rezultata korišćene su deskriptivne i
analitičke statisitičke meto...de.
Rezultati: Učestalost MS u populaciji trudnica bila je 31,1%. Nakon kontrole na
poznati konfaunding faktor uzrast, registrovano je da su trudnice sa MS imale 1,685
puta veću šansu za da im se porođaj završi carskim rezom (OR=1,685, p=0,048), da je
MS bio statistički značajan prognostički faktor ranijih nedelja gestacije na porođaju
(p=0,001), te da je MS bio statistički značajan prognostički faktor niže vrednosti Apgar
skora novorođenčadi (p=0,003).
Zaključak: Rana detekcija MS tokom trudnoće smanjuje perinatalni morbiditet i
značajan je činilac kako toka tako i ishoda trudnoće.
Introduction: The term metabolic syndrome (MS), syndrome of insulin resistance
and syndrome X has been used to precisely define the associated abnormalities which
are associated with an increased risk for the development of type 2 diabetes mellitus, as
well as atherosclerotic cardiovascular disease. The uniform definition of the MS does
not exist.
Objectives: Determining the incidence of MS in the tested sample; testing
connectivity between the main socio - demographic characteristics of pregnant women
and MS; the presence of specific habits of pregnant women and MS; testing of
individual components of MS in pregnancy; the prognostic significance of the metabolic
syndrome in assessing the course and outcome of pregnancy.
Material and methods: Prospective cohort study included 135 pregnant women
hospitalized in the period 2013 and 2014 year. Medical documentation of the Clinics for
Gynecology and Obstetrics, Clinical center Serbia was used, as well the structural
question -... mark for pregnant women. Data analysis included descriptive and analytical
methods.
Results: The incidence of MS in the population of pregnant women was 31,1%.
After controlling for the known confounding factor of age, we confirmed that women
with MS had 1,685 times more likely to finish their birth by caesarean section (OR =
1.685, p = 0.048); that the MS was statistically significant prognostic factor in the
earlier weeks of delivery (p = 0.001); also that the MS was statistically significant
prognostic factor of lower Apgar scores in newborns (p = 0.003).
Conclusion: The early detection of MS during pregnancy reduces perinatal morbidity
and is an important factor for the pregnancy outcome.